2026-09-13T15:11:00Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/53212022-04-07T10:00:26Zcom_10259_4313com_10259_5086com_10259_2604col_10259_4314

00925njm 22002777a 4500 dc Guembe García, Marta author Peredo Guzmán, Patricia D. author Santaolalla García, Victoria author Moradillo Renuncio, Natalia author Ibeas Cortes, Saturnino author Mendía Jalón, Aránzazu author García García, Félix Clemente author García Pérez, José Miguel author Vallejos Calzada, Saúl author 2020-06 We anchored a colourimetric probe, comprising a complex containing copper (Cu(II)) and a dye, to a polymer matrix obtaining film‐shaped chemosensors with induced selectivity toward glycine. This sensory material is exploited in the selectivity detection of glycine in complex mixtures of amino acids mimicking elastin, collagen and epidermis, and also in following the protease activity in a beefsteak and chronic human wounds. We use the term inducing because the probe in solution is not selective toward any amino acid and we get selectivity toward glycine using the solid‐state. Overall, we found that the chemical behaviour of a chemical probe can be entirely changed by changing its chemical environment. Regarding its behaviour in solution, this change has been achieved by isolating the probe by anchoring the motifs in a polymer matrix, in an amorphous state, avoiding the interaction of one sensory motif with another. Moreover, this selectivity change can be further tuned because of the effectiveness of the transport of targets both by the physical nature of the interface of the polymer matrix/solution, where the target chemicals are dissolved, for instance, and inside the matrix where the recognition takes place. The interest in chronic human wounds is related to the fact that our methods are rapid and inexpensive, and also considering that the protease activity can correlate with the evolution of chronic wounds. http://hdl.handle.net/10259/5321 10.3390/polym12061249 2073-4360 solid‐state chemosensors sensory polymers amino acids chronic wounds Why is the Sensory Response of Organic Probes within a Polymer Film Different in Solution and in the Solid-State? Evidence and Application to the Detection of Amino Acids in Human Chronic Wounds