2026-04-17T12:23:10Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/53212022-04-07T10:00:26Zcom_10259_4313com_10259_5086com_10259_2604col_10259_4314

Guembe García, Marta 9c4f2b3d-87cf-461b-b10e-563a95dabb53 500 Peredo Guzmán, Patricia D. 7371d506-f26c-45dd-a1f0-17b8b76d5e95 500 Santaolalla García, Victoria 04252d2c-298c-49e7-8105-547ae182df66 500 Moradillo Renuncio, Natalia 2ecaf58e-cabc-4bca-930b-8c4ab510577d 500 Ibeas Cortes, Saturnino 293 500 Mendía Jalón, Aránzazu 362 500 García García, Félix Clemente 201 500 García Pérez, José Miguel 213 500 Vallejos Calzada, Saúl 567 500 2020-06-03T08:52:19Z 2020-06-03T08:52:19Z 2020-06 http://hdl.handle.net/10259/5321 10.3390/polym12061249 2073-4360 We anchored a colourimetric probe, comprising a complex containing copper (Cu(II)) and a dye, to a polymer matrix obtaining film‐shaped chemosensors with induced selectivity toward glycine. This sensory material is exploited in the selectivity detection of glycine in complex mixtures of amino acids mimicking elastin, collagen and epidermis, and also in following the protease activity in a beefsteak and chronic human wounds. We use the term inducing because the probe in solution is not selective toward any amino acid and we get selectivity toward glycine using the solid‐state. Overall, we found that the chemical behaviour of a chemical probe can be entirely changed by changing its chemical environment. Regarding its behaviour in solution, this change has been achieved by isolating the probe by anchoring the motifs in a polymer matrix, in an amorphous state, avoiding the interaction of one sensory motif with another. Moreover, this selectivity change can be further tuned because of the effectiveness of the transport of targets both by the physical nature of the interface of the polymer matrix/solution, where the target chemicals are dissolved, for instance, and inside the matrix where the recognition takes place. The interest in chronic human wounds is related to the fact that our methods are rapid and inexpensive, and also considering that the protease activity can correlate with the evolution of chronic wounds. FEDER (Fondo Europeo de Desarrollo Regional), and both the Spanish Ministerio de Economía, Industria y Competitividad (MAT2017‐84501‐R) and the Consejería de Educación—Junta de Castilla y León (BU061U16) application/pdf eng MDPI Polymers. 2020, V. 12, n. 6, 1249 https://doi.org/10.3390/polym12061249 info:eu-repo/grantAgreement/MINECO/MAT2017‐84501‐R info:eu-repo/grantAgreement/JCyL/BU061U16 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess solid‐state chemosensors sensory polymers amino acids chronic wounds Química Chemistry Why is the Sensory Response of Organic Probes within a Polymer Film Different in Solution and in the Solid-State? Evidence and Application to the Detection of Amino Acids in Human Chronic Wounds info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Polymers 12 6 1249 TEXT Guembe-polymers_2020.pdf.txt Guembe-polymers_2020.pdf.txt Extracted text text/plain 83240 https://riubu.ubu.es/bitstream/10259/5321/5/Guembe-polymers_2020.pdf.txt d1ae408220dc43c54a61ccad0d4d1f21 MD5 5 THUMBNAIL Guembe-polymers_2020.pdf.jpg Guembe-polymers_2020.pdf.jpg IM Thumbnail image/jpeg 4455 https://riubu.ubu.es/bitstream/10259/5321/4/Guembe-polymers_2020.pdf.jpg 83e3e583b7af397791c5e09e5efc8b9c MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 998 https://riubu.ubu.es/bitstream/10259/5321/3/license.txt aa90105e1c90a1b4fe810649aa967b7d MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 908 https://riubu.ubu.es/bitstream/10259/5321/2/license_rdf 0175ea4a2d4caec4bbcc37e300941108 MD5 2 ORIGINAL Guembe-polymers_2020.pdf Guembe-polymers_2020.pdf application/pdf 1135519 https://riubu.ubu.es/bitstream/10259/5321/1/Guembe-polymers_2020.pdf 76d49f75dd4996e9b5b969d238ea9d3b MD5 1 10259/5321 oai:riubu.ubu.es:10259/5321 2022-04-07 12:00:26.892 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es RWwgYXV0b3IgY29tbyDDum5pY28gdGl0dWxhciBkZSBsb3MgZGVyZWNob3MgZGUgcHJvcGllZGFkIGludGVsZWN0dWFsIGRlIGxhIG9icmEsIG8gZGlzcG9uaWVuZG8gZGUgbG9zIGRlYmlkb3MgcGVybWlzb3MgZGUgbG9zIG90cm9zIHRpdHVsYXJlcywgc2kgbG9zIGh1YmllcmEsIHkgZW4gdmlydHVkIGRlIGxvcyBkZXJlY2hvcyBxdWUgbGUgY29uZmllcmUgbGEgbGVnaXNsYWNpw7NuIHZpZ2VudGUgc29icmUgcHJvcGllZGFkIGludGVsZWN0dWFsIHkgZGVyZWNob3MgZGUgYXV0b3IsIA0KQVVUT1JJWkEgYSBsYSBVbml2ZXJzaWRhZCBkZSBCdXJnb3MgYSBkaWZ1bmRpciwgZGUgbWFuZXJhIGdyYXR1aXRhLCBlbCBjb250ZW5pZG8gZGUgbG9zIGFyY2hpdm9zIGRpZ2l0YWxlcyBxdWUgY29ycmVzcG9uZGVuIGFsIGRvY3VtZW50byBkZXNjcml0byBhbnRlcmlvcm1lbnRlLCBjb24gY2Fyw6FjdGVyIG5vIGV4Y2x1c2l2byB5IGRlIG1hbmVyYSBww7pibGljYSBlbiBhY2Nlc28gYWJpZXJ0byBhIHRyYXbDqXMgZGUgSW50ZXJuZXQsIHBhcmEgbG8gcXVlIGxhIEJpYmxpb3RlY2EgcHJvY2VkZXLDoSBhIGFyY2hpdmFybG9zIGVuIGVsIFJlcG9zaXRvcmlvIEluc3RpdHVjaW9uYWwuIEFzaW1pc21vIGF1dG9yaXphIGEgbGEgVW5pdmVyc2lkYWQgZGUgQnVyZ29zIGEgcmVhbGl6YXIgbGFzIHRyYW5zZm9ybWFjaW9uZXMgbmVjZXNhcmlhcyBkZSBmb3JtYXRvLCBubyBkZSBjb250ZW5pZG8sIHBhcmEgZ2FyYW50aXphciBsYSBwcmVzZXJ2YWNpw7NuIHkgZWwgYWNjZXNvIGVuIGVsIGZ1dHVyby4NCg0KRWwgYXV0b3IgZGlzcG9uZSwgZW4gdG9kbyBjYXNvLCBkZWwgZGVyZWNobyBhIHJldm9jYXIgZXN0YSBhdXRvcml6YWNpw7NuLg0KDQpMYSBjZXNpw7NuIGRlIGRlcmVjaG9zIGRlIGVzdGEgb2JyYSBzZSBlbmN1ZW50cmEgc3VqZXRhIGEgbGEgbGVnaXNsYWNpw7NuIHZpZ2VudGUgc29icmUgcHJvcGllZGFkIGludGVsZWN0dWFsIHkgZGVyZWNob3MgZGUgYXV0b3I=