2026-04-20T00:13:23Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/53232022-04-07T10:19:07Zcom_10259_4249com_10259_5086com_10259_2604col_10259_4250

Rubio Martínez, Laura 492 500 Valverde Som, Lucía 583 500 Sarabia Peinador, Luis Antonio 534 500 Ortiz Fernández, Mª Cruz 406 500 2020-06-03T10:53:08Z 2020-06-03T10:53:08Z 2019-01 0039-9140 http://hdl.handle.net/10259/5323 10.1016/j.talanta.2019.120156 The simultaneous determination of 2,6-di-tert-butyl-4-methyl-phenol (BHT), benzophenone (BP), benzophenone-3 (BP3) and diisobutyl phthalate (DiBP) in seven sunscreen creams was carried out by gas chromatography/mass spectrometry (GC/MS) using DiBP-d4 as internal standard. The content of BP3, which is a UV filter, must not exceed 6% (w/w) in cosmetic products according to Regulation (EU) 2017/238 and the use of DiBP in cosmetic products shall be prohibited according to Regulation (EC) No 1223/2009. The conclusions obtained with the univariate standard methodology in the identification of the analytes contained in the creams were wrong. However, a calibration based on PARAFAC or PARAFAC2 decompositions, where the samples of the prediction set were projected on the model obtained previously with the calibration set, enabled the unequivocal identification and quantification of the analytes even in the presence of interferents not considered in the calibration model. The PARAFAC2 decomposition was used to overcome the shifts in the retention time of BP and BP3. These three-way calibration techniques are needed to avoid false negative results. The method had not proportional or constant bias. The presence of BHT was detected in the seven sunscreen creams analysed at an amount of 6.48 10−2%, 8.53 10−2%, 1.70 10−4%, 1.11 10−4%, 2.51 10−3%, 3.20 10−5% and 6.35 10−3%. The concentrations of DiBP found in four creams were 3.49 10−2%, 3.19 10−2%, 3.26 10−2% and 2.51 10−2%. On the other hand, BP was only detected in two of the cosmetic creams analysed at an amount of 7.84 10−3% and 1.04 10−2%. In addition, BP3 was detected in six of the creams at an amount of 4.73%, 3.49%, 4.94 10−3%, 1.98 10−3%, 6.62 10−1% and 1.73%. Therefore, none of the cosmetic creams contained BP3 in an amount higher than 6%. Spanish MINECO (AEI/FEDER, UE) through project CTQ2017‐88894‐R and by Junta de Castilla y León through project BU012P17 (both co‐financed with European FEDER funds). L. Valverde-Som thanks JCyL for her postdoctoral contract through BU012P17 project. application/pdf eng Elsevier Talanta. 2019, V. 205, 120156 https://doi.org/10.1016/j.talanta.2019.120156 info:eu-repo/grantAgreement/MINECO/CTQ2017‐88894‐R info:eu-repo/grantAgreement/JCyL/BU012P17 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Benzophenone-3 PTV-GC/MS PARAFAC PARAFAC2 UV filter Sunscreen cream Química analítica Chemistry, Analytic Improvement in the identification and quantification of UV filters and additives in sunscreen cosmetic creams by gas chromatography/mass spectrometry through three-way calibration techniques info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Talanta 205 120156 TEXT Rubio-talanta_2019.pdf.txt Rubio-talanta_2019.pdf.txt Extracted text text/plain 69816 https://riubu.ubu.es/bitstream/10259/5323/5/Rubio-talanta_2019.pdf.txt 53db947621e7a96263305b18b1f5f9df MD5 5 THUMBNAIL Rubio-talanta_2019.pdf.jpg Rubio-talanta_2019.pdf.jpg IM Thumbnail image/jpeg 4438 https://riubu.ubu.es/bitstream/10259/5323/4/Rubio-talanta_2019.pdf.jpg 54b235d6159825012067ac492c94dcdf MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 998 https://riubu.ubu.es/bitstream/10259/5323/3/license.txt aa90105e1c90a1b4fe810649aa967b7d MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 805 https://riubu.ubu.es/bitstream/10259/5323/2/license_rdf 4460e5956bc1d1639be9ae6146a50347 MD5 2 ORIGINAL Rubio-talanta_2019.pdf Rubio-talanta_2019.pdf application/pdf 779327 https://riubu.ubu.es/bitstream/10259/5323/1/Rubio-talanta_2019.pdf 730d43f254e2c91dea25151a98e6e0c1 MD5 1 10259/5323 oai:riubu.ubu.es:10259/5323 2022-04-07 12:19:07.363 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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