2026-10-12T10:53:16Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/53652021-11-02T12:02:54Zcom_10259_5363com_10259_5086com_10259_2604col_10259_5364

Gargouri, Wafa Osés Gómez, Sandra María Fernández Muiño, Miguel Ángel Sancho Ortiz, María Teresa Kechaou, Nabil 2020-07-02T09:35:44Z 2020-07-02T09:35:44Z 2019-08 0023-6438 http://hdl.handle.net/10259/5365 10.1016/j.lwt.2019.05.044 The aim of this study was to investigate the phytochemical composition and biological properties of Tunisian propolis from four different regions: Kasserine, Béja, Kèf and Monastir. Ethanolic extracts of propolis were prepared using two extraction methods; solvent and ultrasonic extraction. Total phenolics, flavonoids, ABTS free radical and hydroxyl radicals scavenging abilities, anti-inflammatory, anti-hypertensive, as well as antimicrobial activities of propolis extracts were determined. Identification and quantification of phenolic and flavonoid compounds were performed by using both HPLC-UV and HPLC-ESI-MS. The results revealed high contents of total phenolics and flavonoids and polyphenols extraction was more efficient by sonication. Caffeic acid phenethyl ester (CAPE), galangin, and genistein were the major identified compounds. Antihypertensive activity, evaluated in propolis extracts for first time by HPLC-UV, was higher than 90% for all extracts. Tunisian propolis is an important natural source of polyphenols and flavonoids. The best extraction method was ultrasonic for antioxidants and most of biological activities; conventional method seems to be more suitable for anti-inflammatory activity. Propolis from Béja contains the highest amount of antioxidants and have a stronger potential biological activities. Tunisian propolis could be, therefore, a promising raw material for food and pharmaceutical industry. application/pdf eng Elsevier LWT. 2019, V. 111, p. 328-336 https://doi.org/10.1016/j.lwt.2019.05.044 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Propolis Phenolics HPLC-UV Antioxidant activity ACE Alimentos Food Evaluation of bioactive compounds and biological activities of Tunisian propolis info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion LWT 111 328 336