2026-05-30T15:09:09Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/53702021-11-02T12:01:31Zcom_10259_3924com_10259_5086com_10259_2604col_10259_3925
Repositorio Institucional de la Universidad de Burgos
author
Soto Cerrato, Vanessa
author
Manuel Manresa, Pilar .
author
Hernando Santa Cruz, Elsa
author
Calabuig Fariñas, Silvia
author
Martínez Romero, Alicia
author
Fernández Dueñas, Víctor
author
Sahlholm, Kristoffer
author
Knöpfel, Thomas
author
García Valverde, María
author
Rodilla, Ananda M.
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Jantus Lewintre, Eloisa
author
Farràs, Rosa
author
Ciruela, Francisco
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Pérez Tomás, Ricardo
author
Quesada Pato, Roberto
2020-07-10T09:36:52Z
2020-07-10T09:36:52Z
2015-12
0002-7863
http://hdl.handle.net/10259/5370
10.1021/jacs.5b09970
1520-5126
Facilitated anion transport potentially represents a powerful tool to modulate various cellular functions. However, research into the biological effects of small molecule anionophores is still at an early stage. Here we have used two potent anionophore molecules inspired in the structure of marine metabolites tambjamines to gain insight into the effect induced by these compounds at the cellular level. We show how active anionophores, capable of facilitating the transmembrane transport of chloride and bicarbonate in model phospholipid liposomes, induce acidification of the cytosol and hyperpolarization of plasma cell membranes. We demonstrate how this combined effect can be used against cancer stem cells (CSCs). Hyperpolarization of cell membrane induces cell differentiation and loss of stemness of CSCs leading to effective elimination of this cancer cell subpopulation.
eng
Facilitated Anion Transport Induces Hyperpolarization of the Cell Membrane That Triggers Differentiation and Cell Death in Cancer Stem Cells
info:eu-repo/semantics/article
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URL
https://riubu.ubu.es/bitstream/10259/5370/1/Soto-jacs_2015.pdf
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Soto-jacs_2015.pdf
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https://riubu.ubu.es/bitstream/10259/5370/4/Soto-jacs_2015.pdf.txt
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text/plain
Soto-jacs_2015.pdf.txt