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2020-12-10T12:11:04Z urn:hdl:10259/5576 Supercritical CO2 processing of omega-3 polyunsaturated fatty acids – Towards a biorefinery for fish waste valorization Melgosa Gómez, Rodrigo Sanz Díez, Mª Teresa Beltrán Calvo, Sagrario Fish oil Omega-3 polyunsaturated fatty acids Biorefinery Supercritical carbon dioxide Enzyme Driven by growing prevalence of chronic diseases and consumer’s health awareness, food supplements and nutraceuticals based on omega-3 polyunsaturated fatty acids (PUFAs) are extensively marketed nowadays. However, commercial omega-3 concentrates still present quality issues related to their purity, bioavailability, and easily-oxidizable nature, compelling the industry to seek for more efficient extraction, concentration and formulation methods. Technologies based on the use of supercritical CO2 (scCO2) are a promising alternative, replacing conventional organic solvents and providing milder conditions and an inert atmosphere, which reduce the risk of oxidation. The present review analyzes the latest advances on the use of scCO2 for processing omega-3 PUFAs, focusing on its application in biorefinery strategies for the valorization of fish by-products. Still, further research on process fundamentals is necessary in order to increase the omega-3 yield and purity while reducing the use of energy and auxiliary materials, especially in the transesterification and concentration steps. 2020-12-10T12:11:04Z 2020-12-10T12:11:04Z 2021-02 info:eu-repo/semantics/article 0896-8446 http://hdl.handle.net/10259/5576 10.1016/j.supflu.2020.105121 eng The Journal of Supercritical Fluids. 2020, V. 169, 105121 https://doi.org/10.1016/j.supflu.2020.105121 info:eu-repo/grantAgreement/AEI/PID2019-539 104950RB-I00 / AEI / 10.13039/501100011033 info:eu-repo/grantAgreement/JCyL/BU301P18 info:eu-repo/grantAgreement/JCyL/BU050P20 http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier