2026-04-20T01:52:33Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/56312022-11-21T12:01:24Zcom_10259_4249com_10259_5086com_10259_2604col_10259_4250

Arce Antón, Mar 34 500 Ruiz Miguel, Santiago 501 500 Sanllorente Méndez, Silvia 522 500 Ortiz Fernández, Mª Cruz 406 500 Sarabia Peinador, Luis Antonio 534 500 Sánchez Pastor, Mª Sagrario 518 500 2021-03-01T13:02:34Z 2021-03-01T13:02:34Z 2021 0003-2670 http://hdl.handle.net/10259/5631 10.1016/j.aca.2021.338217 The paper shows a procedure for selecting the control method parameters (factors) to obtain a preset ‘analytical target profile’ when a liquid chromatographic technique is going to be carried out for the simultaneous determination of five bisphenols (bisphenol-A, bisphenol-S, bisphenol-F, bisphenol-Z and bisphenol-AF), some of them regulated by the European Union. The procedure has three steps. The first consists of building a D-optimal combined design (mixture-process design) for the control method parameters, which are the composition of the ternary mobile phase and its flow rate. The second step is to fit a PLS2 model to predict six analytical responses (namely, the resolution between each pair of consecutive peaks, and the initial and final chromatographic time) as a function of the control method parameters. The third final step is the inversion of the PLS2 model to obtain the conditions needed for attaining a preset analytical target profile. The computational inversion of the PLS2 prediction model looking for the Pareto front of these six responses provides a set of experimental conditions to conduct the chromatographic determination, specifically 22% of water, mixed with 58% methanol and 20% of acetonitrile, keeping the flow rate at 0.66 mL min−1. These conditions give a chromatogram with retention times of 2.180, 2.452, 2.764, 3.249 and 3.775 min for BPS, BPF, BPA, BPAF and BPZ, respectively, and excellent resolution among all the chromatographic peaks. Finally, the analytical method is validated under the selected experimental conditions, in terms of trueness and precision. In addition, the detection capability for the five bisphenols were: 596, 334, 424, 458 and 1156 μg L−1, with probabilities of false positive and of false negative equal to 0.05. Spanish MINECO (AEI/FEDER, UE) and Consejería de Educación de la JCyL through projects CTQ2017-88894-R and BU052P20, co-financed with European Regional Development Funds application/pdf eng Elsevier Analytica Chimica Acta. 2021, V. 1149, 338217 https://doi.org/10.1016/j.aca.2021.338217 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-88894-R/ES/NUEVAS HERRAMIENTAS QUIMIOMETRICAS CON VARIABLES LATENTES PARA LA TOMA DE DECISIONES EN TECNOLOGIA ANALITICA DE PROCESOS Y EN CONTEXTOS REGULADOS DE SEGURIDAD ALIMENTARIA info:eu-repo/grantAgreement/Junta de Castilla y León//BU052P20//Nuevos desarrollos metodológicos del diseño de experimentos para análisis químicos, bioquímicos y en tecnología analítica de procesos Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Process analytical technology Partial least squares Pareto optimality Bisphenol AHPLC-DAD Computational latent variable model inversion Química analítica Chemistry, Analytic A new approach based on inversion of a partial least squares model searching for a preset analytical target profile. Application to the determination of five bisphenols by liquid chromatography with diode array detector info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Analytica Chimica Acta 1149 338217 TEXT Arce-aca_2021.pdf.txt Arce-aca_2021.pdf.txt Extracted text text/plain 75129 https://riubu.ubu.es/bitstream/10259/5631/5/Arce-aca_2021.pdf.txt 89f977b12d45750425a7ae0d30ebdaf0 MD5 5 THUMBNAIL Arce-aca_2021.pdf.jpg Arce-aca_2021.pdf.jpg IM Thumbnail image/jpeg 4529 https://riubu.ubu.es/bitstream/10259/5631/4/Arce-aca_2021.pdf.jpg 666861ef0275ab7ba1d765768f485902 MD5 4 Arce-Aca_2021.pdf.jpg Arce-Aca_2021.pdf.jpg IM Thumbnail image/jpeg 4923 https://riubu.ubu.es/bitstream/10259/5631/7/Arce-Aca_2021.pdf.jpg 45a6a4a62fea4da87d0cfcc3597bca72 MD5 7 LICENSE license.txt license.txt text/plain; charset=utf-8 998 https://riubu.ubu.es/bitstream/10259/5631/3/license.txt aa90105e1c90a1b4fe810649aa967b7d MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 805 https://riubu.ubu.es/bitstream/10259/5631/2/license_rdf 4460e5956bc1d1639be9ae6146a50347 MD5 2 ORIGINAL Arce-Aca_2021.pdf Arce-Aca_2021.pdf application/pdf 1057586 https://riubu.ubu.es/bitstream/10259/5631/6/Arce-Aca_2021.pdf ac5ce31972ce5f8ea65868de534af303 MD5 6 10259/5631 oai:riubu.ubu.es:10259/5631 2022-11-21 13:01:24.053 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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