2026-04-27T14:20:43Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/56442024-07-25T07:19:48Zcom_10259_9476com_10259.4_106com_10259_2604col_10259_9477

Domi, Brixhilda 791 500 0000-0001-7786-8615 Bhorkar, Kapil e3598e01-5cec-4cfb-bed1-406ae8b1019a 500 Rumbo Lorenzo, Carlos 505 500 0000-0002-5038-0334 Sygellou, Labrini 2c3bf496-8ed4-4640-bbcc-cf086f807e28 500 Martel Martín, Sonia 790 500 0000-0001-9080-0877 Quesada Pato, Roberto 458 500 0000-0003-2764-7157 Yannopoulos, Spyros N. a42c587c-31c0-43bf-9ffb-62ab92f95abf 500 Tamayo Ramos, Juan Antonio 547 500 0000-0002-7071-002X 2021-03-12T13:06:31Z 2021-03-12T13:06:31Z 2021-06 0045-6535 http://hdl.handle.net/10259/5644 10.1016/j.chemosphere.2021.129603 The utilization of tungsten disulfide (WS2) nanomaterials in distinct applications is raising due to their unique physico-chemical properties, such as low friction coefficient and high strength, which highlights the necessity to study their potential toxicological effects, due to the potential increase of environmental and human exposure. The aim of this work was to analyze commercially available aqueous dispersions of monolayer tungsten disulfide (2D WS2) nanomaterials with distinct lateral size employing a portfolio of physico-chemical and toxicological evaluations. The structure and stoichiometry of monolayer tungsten disulfide (WS2-ACS-M) and nano size monolayer tungsten disulfide (WS2-ACS-N) was analyzed by Raman spectroscopy, whereas a more quantitative approach to study the nature of formed oxidized species was undertaken employing X-ray photoelectron spectroscopy. Adenocarcinomic human alveolar basal epithelial cells (A549 cells) and the ecotoxicology model Saccharomyces cerevisiae were selected as unicellular eukaryotic systems to assess the cytotoxicity of the nanomaterials. Cell viability and reactive oxygen species (ROS) determinations demonstrated different toxicity levels depending on the cellular model used. While both 2D WS2 suspensions showed very low toxicity towards the A549 cells, a comparable concentration (160 mg L−1) reduced the viability of yeast cells. The toxicity of a nano size 2D WS2 commercialized in dry form from the same provider was also assessed, showing ability to reduce yeast cells viability as well. Overall, the presented data reveal the physico-chemical properties and the potential toxicity of commercial 2D WS2 aqueous suspensions when interacting with distinct eukaryotic organisms, showing differences in function of the biological system exposed. European Union’s H2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement N. 721642 application/pdf eng Elsevier Chemosphere. 2021, V. 272, 129603 https://doi.org/10.1016/j.chemosphere.2021.129603 info:eu-repo/grantAgreement/EC/H2020/721642/EU/Solid lubrication for emerging engineering applications Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess 2D WS2 StructureStoichiometry Eukaryotic cells Cell viability Oxidative stress Toxicological assessment of commercial monolayer tungsten disulfide nanomaterials aqueous suspensions using human A549 cells and the model fungus Saccharomyces cerevisiae info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Chemosphere 272 129603 TEXT Domi-Chemosphere_2021.pdf.txt Domi-Chemosphere_2021.pdf.txt Extracted text text/plain 49694 https://riubu.ubu.es/bitstream/10259/5644/5/Domi-Chemosphere_2021.pdf.txt 3635c1514458ec5c59280e0cad180287 MD5 5 THUMBNAIL Domi-Chemosphere_2021.pdf.jpg Domi-Chemosphere_2021.pdf.jpg IM Thumbnail image/jpeg 4572 https://riubu.ubu.es/bitstream/10259/5644/4/Domi-Chemosphere_2021.pdf.jpg 70af6cbdd3c336b534aa0b9b149ba869 MD5 4 Domi-CHemosphere_2021.pdf.jpg Domi-CHemosphere_2021.pdf.jpg IM Thumbnail image/jpeg 4928 https://riubu.ubu.es/bitstream/10259/5644/7/Domi-CHemosphere_2021.pdf.jpg d3ee3f01676aef651d57a456f155f9b6 MD5 7 LICENSE license.txt license.txt text/plain; charset=utf-8 998 https://riubu.ubu.es/bitstream/10259/5644/3/license.txt aa90105e1c90a1b4fe810649aa967b7d MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 805 https://riubu.ubu.es/bitstream/10259/5644/2/license_rdf 4460e5956bc1d1639be9ae6146a50347 MD5 2 ORIGINAL Domi-CHemosphere_2021.pdf Domi-CHemosphere_2021.pdf application/pdf 2314849 https://riubu.ubu.es/bitstream/10259/5644/6/Domi-CHemosphere_2021.pdf 745178bc34e6fb7939964e99b10f1969 MD5 6 10259/5644 oai:riubu.ubu.es:10259/5644 2024-07-25 09:19:48.656 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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