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oai:riubu.ubu.es:10259/58052023-09-30T22:42:12Zcom_10259_4249com_10259_5086com_10259_2604col_10259_4250

Arce Antón, Mar 34 500 0000-0003-0921-5457 Ortiz Fernández, Mª Cruz 406 500 0000-0002-4751-8929 Sanllorente Méndez, Silvia 522 500 0000-0001-8693-8806 2021-06-15T08:29:13Z 2021-06-15T08:29:13Z 2021-09 0026-265X http://hdl.handle.net/10259/5805 10.1016/j.microc.2021.106413 Bisphenol A (BPA) is considered an endocrine disrupting chemical as it affects the human hormonal system and is widely used in polycarbonate (PC) manufacture. As the population is continually exposed to BPA, European regulations have limited its industrial use in cosmetics, thermal paper, toys and food contact materials. Because of these restrictions, other bisphenols are replacing BPA, but they show similar harmful effects as BPA. In this work, migration of five bisphenols (BPS, BPF, BPA, BPAF, BPZ) from BPA-free PC glasses into simulant B (3% acetic acid (w/v) in aqueous solution) has been determined by means of HPLC-DAD. For this task, twenty glasses were exposed to a migration test at 70 °C for 24 h, more severe conditions than the ones suggested in technical guides. Afterwards, PARAFAC (parallel factor analysis) decomposition, validation of PARAFAC models, and evaluation of CCα (decision limit) and CCβ (detection capability) were carried out. A study was performed by comparing the population results (concentration), obtained for analytical blanks (n = 40) versus the ones obtained for the migration test from BPA-free polycarbonate glasses (n = 40) by means of the corresponding probability density functions fitted for both populations. A statistically significant difference between both populations was only found for BPA. BPA migrated from PC glasses with concentration greater than 0.49 μg L-1, for probabilities of false positive (α) and false negative (β) equal to 0.05 and 0.07, respectively. However, the maximum amount of BPA migrated from PC glasses was 5.60 μg L-1, a value lower than the established limit for the specific migration of a non-authorised substance (10 μg kg−1). Spanish MINECO (AEI/FEDER, UE) and Consejería de Educación de la Junta de Castilla y León through projects CTQ2017-88894-R and BU052P20 respectively (all co-financed with FEDER funds). M.M. Arce wish to thank JCyL for her postdoctoral contract through BU052P20 application/pdf eng Elsevier Microchemical Journal. 2021 V. 168, 106413 https://doi.org/10.1016/j.microc.2021.106413 info:eu-repo/grantAgreement/MINECO/CTQ2017-88894-R info:eu-repo/grantAgreement/JCyL/BU052P20 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Bisphenols Migration BPA-free glass HPLC-DAD PARAFAC Food Contact Materials Química analítica Chemistry, Analytic HPLC-DAD and PARAFAC for the determination of bisphenol-A and another four bisphenols migrating from BPA-free polycarbonate glasses info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Microchemical Journal 168 106413 THUMBNAIL Arce-mj_2021.pdf.jpg Arce-mj_2021.pdf.jpg IM Thumbnail image/jpeg 4432 https://riubu.ubu.es/bitstream/10259/5805/4/Arce-mj_2021.pdf.jpg 1fdc01e76afa1c90a5c2d390fe278a2b MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 998 https://riubu.ubu.es/bitstream/10259/5805/3/license.txt aa90105e1c90a1b4fe810649aa967b7d MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 805 https://riubu.ubu.es/bitstream/10259/5805/2/license_rdf 4460e5956bc1d1639be9ae6146a50347 MD5 2 ORIGINAL Arce-mj_2021.pdf Arce-mj_2021.pdf application/pdf 939362 https://riubu.ubu.es/bitstream/10259/5805/1/Arce-mj_2021.pdf 346ce2bd427b35548af90804caf39451 MD5 1 10259/5805 oai:riubu.ubu.es:10259/5805 2023-10-01 00:42:12.968 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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