2026-06-18T01:07:50Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/60902022-12-02T01:05:49Zcom_10259_3593com_10259_5086com_10259_2604col_10259_3594

00925njm 22002777a 4500 dc Martínez Lara, Fernando author Suárez, Anisley author Velasco Pérez, Noelia author Suarez Pantiga, Samuel author Sanz Díez, Roberto author 2022-01 Propargylic glycols, 2-alkynyl-1-(indol-3-yl)-1,2-diols, react with thiols undergoing a complex but selective gold-catalyzed transformation that gives rise to α-indol-3-yl α-((Z)-2-thioalkenyl) ketones. The sequence is triggered by the regioselective thiolation of indolyl diols followed by an attack of the sulfur instead of the indole over the activated alkyne. The final compounds are obtained in remarkably high yields and arise from simple starting materials such as indolyl acyloins, ethynyl magnesium bromide and thiols. 1615-4169 http://hdl.handle.net/10259/6090 10.1002/adsc.202100930 Gold Homogeneous catalysis Nitrogen heterocycles Rearrangement Sulfur Gold-Catalyzed Reactions of 2-Alkynyl-1-indolyl-1,2-diols with Thiols: Stereoselective Synthesis of (Z)-α-Indol-3-yl α-(2-Thioalkenyl) Ketones