2026-06-17T21:16:47Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/60932022-11-11T12:52:48Zcom_10259_3593com_10259_5086com_10259_2604col_10259_3594

00925njm 22002777a 4500 dc Velasco Pérez, Noelia author Suárez, Anisley author Martínez Lara, Fernando author Fernández Rodríguez, Manuel A. author Sanz Díez, Roberto author Suarez Pantiga, Samuel author 2021-04 This work describes the 6-endo-dig cyclization of Saryl propargyl sulfides to afford 2H-thiochromenes. The substitution at the propargylic position plays a crucial role in allowing intramolecular silver-catalyzed alkyne hydroarylation and Niodosuccinimide-promoted iodoarylation. Additionally, a PTSAcatalyzed thiolation reaction of propargylic alcohols was developed to synthesize the required tertiary S-aryl propargyl ethers. The applicability of merging these two methods is demonstrated by synthesizing the retinoic acid receptor antagonist AGN194310. 0022-3263 http://hdl.handle.net/10259/6093 10.1021/acs.joc.1c00333 1520-6904 Sulfides Alcohols Column chromatography Cyclization Propargyls From Propargylic Alcohols to Substituted Thiochromenes: gem- Disubstituent Effect in Intramolecular Alkyne Iodo/hydroarylation