2026-07-06T11:10:39Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/62552022-11-09T11:20:33Zcom_10259_4365com_10259_5086com_10259_2604col_10259_4366

Bresciani, Giulio Busto Vázquez, Natalia Ceccherini, Valentina Bortoluzzi, Marco Pampaloni, Guido García Ruiz, Begoña Marchetti, Fabio 2021-12-02T10:24:43Z 2021-12-02T10:24:43Z 2022-02 0162-0134 http://hdl.handle.net/10259/6255 10.1016/j.jinorgbio.2021.111667 We report a screening study aimed to assess for the first time the air- and water-stability and the biological potential of simple metal-carbamates. These molecular metallic species are based on elements belonging to the groups 4–5, 7–9 and 11, and tin, and are easily available from inexpensive reagents. Complexes [Ag(O2CNEt2)] (13-Ag) and [Au(O2CNMe2)(PPh3)] (14-Au) resulted substantially stable in aqueous media and exhibited a potent in vitro cytotoxicity. Especially 13-Ag revealed a significant selectivity against the A549 lung adenocarcinoma and the A2780 ovarian cancer cell lines with respect to the noncancerous HEK293 cell line. Generation of ROS (reactive oxygen species) and mitochondrial membrane depolarization were recognized for 13-Ag and 14-Au; notwithstanding, the cell death mechanism is different in the two cases: apoptosis and cell cycle arrest in G0/G1 phase for 13-Ag; necroptosis and cell cycle arrest in S phase for 14-Au. Both 13-Ag and 14-Au are endowed with antibacterial activity, which is relatively stronger for 13-Ag towards Gram negative and for 14-Au towards Gram positive strains, respectively. La Caixa Foundation (LCF/PR/PR12/11070003), Consejería de Educación-Junta de Castilla y León-FEDER Funds (BU305P18), Ministerio de Ciencia, Innovación y Universidades (RTI2018-102040-B-100) and the University of Pisa (PRA_2020_39). application/pdf eng Elsevier Journal of Inorganic Biochemistry. 2022, V. 227, 111667 https://doi.org/10.1016/j.jinorgbio.2021.111667 info:eu-repo/grantAgreement/Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona//LCF%2FPR%2FPR12%2F11070003 info:eu-repo/grantAgreement/Junta de Castilla y León//BU305P18 info:eu-repo/grantAgreement/University of Pisa//PRA_2020_39 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-102040-B-I00/ES/PROPIEDADES ANTIMICROBIANAS DE NUEVOS COMPLEJOS ORGANOMETALICOS Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Metals in medicine Anticancer metal complexes Transition metal complexes Metal carbamates Cytotoxicity Antibacterial activity Química inorgánica Bioquímica Chemistry, Inorganic Biochemistry Screening the biological properties of transition metal carbamates reveals gold(I) and silver(I) complexes as potent cytotoxic and antimicrobial agents info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion