2026-05-30T19:44:34Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/62552022-11-09T11:20:33Zcom_10259_4365com_10259_5086com_10259_2604col_10259_4366
Repositorio Institucional de la Universidad de Burgos
author
Bresciani, Giulio
author
Busto Vázquez, Natalia
author
Ceccherini, Valentina
author
Bortoluzzi, Marco
author
Pampaloni, Guido
author
García Ruiz, Begoña
author
Marchetti, Fabio
2021-12-02T10:24:43Z
2021-12-02T10:24:43Z
2022-02
0162-0134
http://hdl.handle.net/10259/6255
10.1016/j.jinorgbio.2021.111667
We report a screening study aimed to assess for the first time the air- and water-stability and the biological potential of simple metal-carbamates. These molecular metallic species are based on elements belonging to the groups 4–5, 7–9 and 11, and tin, and are easily available from inexpensive reagents. Complexes [Ag(O2CNEt2)] (13-Ag) and [Au(O2CNMe2)(PPh3)] (14-Au) resulted substantially stable in aqueous media and exhibited a potent in vitro cytotoxicity. Especially 13-Ag revealed a significant selectivity against the A549 lung adenocarcinoma and the A2780 ovarian cancer cell lines with respect to the noncancerous HEK293 cell line. Generation of ROS (reactive oxygen species) and mitochondrial membrane depolarization were recognized for 13-Ag and 14-Au; notwithstanding, the cell death mechanism is different in the two cases: apoptosis and cell cycle arrest in G0/G1 phase for 13-Ag; necroptosis and cell cycle arrest in S phase for 14-Au. Both 13-Ag and 14-Au are endowed with antibacterial activity, which is relatively stronger for 13-Ag towards Gram negative and for 14-Au towards Gram positive strains, respectively.
eng
Atribución 4.0 Internacional
Metals in medicine
Anticancer metal complexes
Transition metal complexes
Metal carbamates
Cytotoxicity
Antibacterial activity
Screening the biological properties of transition metal carbamates reveals gold(I) and silver(I) complexes as potent cytotoxic and antimicrobial agents
info:eu-repo/semantics/article
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URL
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Bresciani-jib_2022.pdf