2026-05-30T13:52:27Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/68192022-08-27T00:05:17Zcom_10259_4354com_10259_5086com_10259_2604col_10259_4355

00925njm 22002777a 4500 dc García Calvo, José author Torroba Pérez, Tomás author Brañas‐Fresnillo, Virginia author Perdomo Hernández, Germán M. author Cózar Castellano, Irene author Li, Yu‐Hao author Legrand, Yves‐Marie author Barboiu, Mihail author 2019-05 The cyclic depsipeptide cereulide toxin it is a very well-known potassium electrogenic ionophore particularly sensitive to pancreatic beta cells. The mechanistic details of its specific activity are unknown. Here, we describe a series of synthetic substituted cereulide potassium ionophores that cause impressive selective activation of glucose-induced insulin secretion in a constitutive manner in rat insulinoma INS1E cells. Our study demonstrates that the different electroneutral K+ transport mechanism exhibited by the anionic mutant depsipeptides when compared with classical electrogenic cereulides can have an important impact of pharmacological value on glucose-stimulated insulin secretion. 0947-6539 http://hdl.handle.net/10259/6819 10.1002/chem.201901372 1521-3765 Biological activity Fluorescent probes Insulin Ionophores Peptides Manipulation of Transmembrane Transport by Synthetic K+ Ionophore Depsipeptides and Its Implications in Glucose‐Stimulated Insulin Secretion in β‐Cells