2026-05-30T14:12:15Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/68192022-08-27T00:05:17Zcom_10259_4354com_10259_5086com_10259_2604col_10259_4355

García Calvo, José Torroba Pérez, Tomás Brañas‐Fresnillo, Virginia Perdomo Hernández, Germán M. Cózar Castellano, Irene Li, Yu‐Hao Legrand, Yves‐Marie Barboiu, Mihail 2022-08-26T11:50:20Z 2022-08-26T11:50:20Z 2019-05 0947-6539 http://hdl.handle.net/10259/6819 10.1002/chem.201901372 1521-3765 The cyclic depsipeptide cereulide toxin it is a very well-known potassium electrogenic ionophore particularly sensitive to pancreatic beta cells. The mechanistic details of its specific activity are unknown. Here, we describe a series of synthetic substituted cereulide potassium ionophores that cause impressive selective activation of glucose-induced insulin secretion in a constitutive manner in rat insulinoma INS1E cells. Our study demonstrates that the different electroneutral K+ transport mechanism exhibited by the anionic mutant depsipeptides when compared with classical electrogenic cereulides can have an important impact of pharmacological value on glucose-stimulated insulin secretion. eng info:eu-repo/semantics/openAccess Biological activity Fluorescent probes Insulin Ionophores Peptides Manipulation of Transmembrane Transport by Synthetic K+ Ionophore Depsipeptides and Its Implications in Glucose‐Stimulated Insulin Secretion in β‐Cells info:eu-repo/semantics/article