2026-06-21T16:09:39Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/71292022-11-22T01:05:33Zcom_10259_5645com_10259_5086com_10259_2604com_10259_4313col_10259_5646col_10259_4314

Guembe García, Marta Santaolalla García, Victoria Moradillo Renuncio, Natalia Ibeas Cortes, Saturnino Reglero Ruiz, José A. García García, Félix Clemente Pacheco Bonrostro, Joaquín Casado Yusta, Silvia García Pérez, José Miguel Vallejos Calzada, Saúl 2022-11-21T11:16:25Z 2022-11-21T11:16:25Z 2021-05 0925-4005 http://hdl.handle.net/10259/7129 10.1016/j.snb.2021.129688 The healing processes in cutaneous wounds, i.e., chronic wounds, represent a health problem affecting 1–2 % of the population. The evaluation of these wounds is mainly based on subjective parameters, although there is a medical consensus on protease activity as the best marker for healing disorders. Here we show the correlation of the amino acid concentration on chronic wounds and with their evolution, and the development of a test kit to straightforward determining this evolution. Our test kit is a colorimetric sensory polymer film that change its colour upon contacting amino acids. The kit allows for the quantification of the overall amino acid concentration by simply analysing the colour definition parameters of the sensory film obtained from of a photograph taken with a smartphone. We analysed with the kit the amino acid concentration of human chronic wounds of 34 patients and we mathematically demonstrate that there is a correlation with the amino acid concentration, related with the protease activity, and the evolution of the wound’s diagnoses. This kit can help diagnosis of human chronic wounds, usually evaluated and treated along time by different physicians, or even by different medical teams, providing an analytical tool not subjected to subjective evaluation. Spanish Ministerio de Economía, Industria y Competitividad (MAT2017-84501-R and ECO2016-76567-C4-2-R) and the Consejería de Educación, Junta de Castilla y León (BU306P18 and BU071G19 application/pdf eng Elsevier Sensors and Actuators B: Chemical. 2021, V. 335, 129688 https://doi.org/10.1016/j.snb.2021.129688 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2017-84501-R/ES/POLIMEROS SENSORES. ETIQUETAS INTELIGENTES CON APLICACION EN BIOMEDICINA Y EN SEGURIDAD ALIMENTARIA info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/ECO2016-76567-C4-2-R/ES/BÚSQUEDA DE LA EFICIENCIA Y SOSTENIBILIDAD DE LAS DECISIONES PÚBLICAS: UN ENFOQUE MULTICRITERIO info:eu-repo/grantAgreement/Junta de Castilla y León//BU306P18//MATERIALES AVANZADOS. POLÍMEROS SENSORES, FILMS Y TEJIDOS COMO MATERIALES INTELIGENTES CON APLICACIÓN EN SEGURIDAD ALIMENTARIA Y EN BIOMEDICINA info:eu-repo/grantAgreement/Junta de Castilla y León//BU071G19//Métodos heurísticos para problemas de optimización de recursos sanitarios con varios objetivos Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Monitoring human chronic wounds Polymer chemosensor Smartphone Química orgánica Química física Química analítica Tecnología Chemistry, Organic Chemistry, Physical and theoretical Chemistry, Analytic Technology Monitoring of the evolution of human chronic wounds using a ninhydrin-based sensory polymer and a smartphone info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Sensors and Actuators B: Chemical 335 129688