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<dc:title>Accelerometer Cut-Points for Physical Activity Assessment in Adults with Mild to Moderate Huntington’s Disease: A Cross-Sectional Multicentre Study</dc:title>
<dc:creator>Simón Vicente, Lucía</dc:creator>
<dc:creator>Rivadeneyra Posadas, Jéssica Jannett</dc:creator>
<dc:creator>Soto Célix, María .</dc:creator>
<dc:creator>Raya-González, Javier</dc:creator>
<dc:creator>Castillo, Daniel</dc:creator>
<dc:creator>Calvo Simal, Sara</dc:creator>
<dc:creator>Collazo Riobó, Carla</dc:creator>
<dc:creator>Rodríguez Fernández, Alejandro</dc:creator>
<dc:creator>Fahed, Vitoria S.</dc:creator>
<dc:creator>Mariscal, Natividad</dc:creator>
<dc:creator>García Bustillo, Álvaro</dc:creator>
<dc:creator>Aguado, Laura</dc:creator>
<dc:creator>Cubo Delgado, Esther</dc:creator>
<dc:subject>Accelerometry</dc:subject>
<dc:subject>Energy metabolism</dc:subject>
<dc:subject>Rehabilitation</dc:subject>
<dc:subject>Actigraphy</dc:subject>
<dc:subject>Calorimetry</dc:subject>
<dc:subject>Indirect</dc:subject>
<dcterms:abstract>Accelerometers can estimate the intensity, frequency, and duration of physical activity&#xd;
in healthy adults. Although thresholds to distinguish varying levels of activity intensity using the&#xd;
Actigraph wGT3X-B have been established for the general population, their accuracy for Huntington’s&#xd;
disease (HD) is unknown. We aimed to define and cross-validate accelerometer cut-points for different&#xd;
walking speeds in adults with mild to moderate HD. A cross-sectional, multicentre, case-control,&#xd;
observational study was conducted with a convenience sample of 13 symptomatic ambulatory HD&#xd;
participants. The accelerometer was placed around the right hip, and a heart monitor was fitted&#xd;
around the chest to monitor heart rate variability. Participants walked on a treadmill at three speeds&#xd;
with light, moderate and vigorous intensities. Correlation and receiver operation curve analyses were&#xd;
performed between the accelerometer magnitude vector with relative oxygen and heart rate. Optimal&#xd;
cut-points for walking speeds of 3.2 km/h were ≤2852; 5.2 km/h: >2852 to ≤4117, and in increments&#xd;
until their maximum velocity: >4117. Our results support the application of the disease-specific&#xd;
cut-points for quantifying physical activity in patients with mild to moderate HD and promoting&#xd;
healthy lifestyle interventions.</dcterms:abstract>
<dcterms:dateAccepted>2023-03-21T12:01:09Z</dcterms:dateAccepted>
<dcterms:available>2023-03-21T12:01:09Z</dcterms:available>
<dcterms:created>2023-03-21T12:01:09Z</dcterms:created>
<dcterms:issued>2022-11</dcterms:issued>
<dc:type>info:eu-repo/semantics/article</dc:type>
<dc:identifier>http://hdl.handle.net/10259/7574</dc:identifier>
<dc:identifier>10.3390/ijerph192214834</dc:identifier>
<dc:identifier>1660-4601</dc:identifier>
<dc:language>eng</dc:language>
<dc:relation>International Journal of Environmental Research and Public Health. 2022, V. 19, n. 22, 14834</dc:relation>
<dc:relation>https://doi.org/10.3390/ijerph192214834</dc:relation>
<dc:relation>info:eu-repo/grantAgreement/Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona//FUI1-PI008/</dc:relation>
<dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
<dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
<dc:rights>Atribución 4.0 Internacional</dc:rights>
<dc:publisher>MDPI</dc:publisher>
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