2026-04-19T16:02:07Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/75792023-04-19T09:40:45Zcom_10259_6256com_10259_5086com_10259_2604col_10259_6257

25-Hydroxyvitamin D Serum Levels Linked to Single Nucleotide Polymorphisms (SNPs) (rs2228570, rs2282679, rs10741657) in Skeletal Muscle Aging in Institutionalized Elderly Men Not Supplemented with Vitamin D Fernández-Lázaro, Diego García Hernández, Juan Luis Lumbreras, Eva Mielgo Ayuso, Juan Seco-Calvo, Jesús Elderly Aging Sarcopenia 25-OH vitamin D Deficiency Genetics CYP2R1 GC VDR Sarcopenia (Sp) is the loss of skeletal muscle mass associated with aging that results in an involution of muscle function and strength. Vitamin D deficiency is a common health problem worldwide, especially among the elderly, and hypovitaminosis D leads to musculoskeletal disorders. The aim of this study was to evaluate the impact and presence of a possible linkage between Single Nucleotide Polymorphisms (SNPs) CYP2R1 (rs10741657), GC (rs2282679), and VDR (rs2228570), serum 25-OH/D concentrations and the link with the degree of sarcopenia in 19 institutionalized elderly men not supplemented with vitamin D. Levels of 25-OH vitamin D were quantified with a commercial enzyme-linked immunosorbent assay kit and 3 SNPs were genotyped with KASPar assays. Significant differences in 25-OH/D concentration were determined between the bi-allelic combinations of rs228679 and rs228570. We detected statistically significant weak positive correlations between the AA (rs10741657 and rs228570) and TT (rs228679) and alleles and 25-OH/D and the probability of having higher 25-OH/D concentrations was 2- to 3-fold higher. However, the GG alleles of the 3 SNPs showed that the probability of having optimal 25-0H/D concentrations decreases by 32% for rs10741657, 38% for rs228679, and 74% for rs228570, showing a strong negative correlation between the degree of sarcopenia and 25-OH/D levels. Allelic variations in CYP2R1 (rs10741657), GC (rs2282679), and VDR (rs10741657) affect vitamin D levels and decisively influence the degree of sarcopenia in institutionalized elderly people. 2023-03-22T08:25:38Z 2023-03-22T08:25:38Z 2023-03-22T08:25:38Z 2022-10 info:eu-repo/semantics/article http://hdl.handle.net/10259/7579 10.3390/ijms231911846 1422-0067 eng International Journal of Molecular Sciences. 2022, V. 23, n. 19, 11846 https://doi.org/10.3390/ijms231911846 info:eu-repo/grantAgreement/UVA//SO-1-2020/ES/ http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Atribución 4.0 Internacional MDPI