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<dc:creator>Fernández-Lázaro, Diego</dc:creator>
<dc:creator>Mielgo Ayuso, Juan</dc:creator>
<dc:creator>Santamaría, Gema</dc:creator>
<dc:creator>Gutiérrez-Abejón, Eduardo</dc:creator>
<dc:creator>Domínguez-Ortega, Carlos</dc:creator>
<dc:creator>García-Lázaro, Sandra María</dc:creator>
<dc:creator>Seco-Calvo, Jesús</dc:creator>
<dc:date>2022-07</dc:date>
<dc:description>Athletes incorporate altitude training programs into their conventional training to improve&#xd;
their performance. The purpose of this study was to determine the effects of an 8-week altitude&#xd;
training program that was supplemented with intermittent hypoxic training (IHE) on the blood&#xd;
biomarkers, sports performance, and safety profiles of elite athletes. In a single-blind randomized&#xd;
clinical trial that followed the CONSORT recommendations, 24 male athletes were randomized to&#xd;
an IHE group (HA, n = 12) or an intermittent normoxia group (NA, n = 12). The IHE consisted&#xd;
of 5-min cycles of hypoxia–normoxia with an FIO2 of between 10–13% for 90 min every day for&#xd;
8 weeks. Hematological (red blood cells, hemoglobin, hematocrit, hematocrit, reticulated hemoglobin,&#xd;
reticulocytes, and erythropoietin), immunological (leukocytes, monocytes, and lymphocytes), and&#xd;
renal (urea, creatinine, glomerular filtrate, and total protein) biomarkers were assessed at the baseline&#xd;
(T1), day 28 (T2), and day 56 (T3). Sports performance was evaluated at T1 and T3 by measuring&#xd;
quadriceps strength and using three-time trials over the distances of 60, 400, and 1000 m on an&#xd;
athletics track. Statistically significant increases (p &lt; 0.05) in erythropoietin, reticulocytes, hemoglobin,&#xd;
and reticulocyte hemoglobin were observed in the HA group at T3 with respect to T1 and the NA&#xd;
group. In addition, statistically significant improvements (p &lt; 0.05) were achieved in all performance&#xd;
tests. No variations were observed in the immunological or renal biomarkers. The athletes who were&#xd;
living and training at 1065 m and were supplemented with IHE produced significant improvements&#xd;
in their hematological behavior and sports performance with optimal safety profiles.</dc:description>
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<dc:identifier>http://hdl.handle.net/10259/7589</dc:identifier>
<dc:language>eng</dc:language>
<dc:publisher>MDPI</dc:publisher>
<dc:title>Adequacy of an Altitude Fitness Program (Living and Training) plus Intermittent Exposure to Hypoxia for Improving Hematological Biomarkers and Sports Performance of Elite Athletes: A Single-Blind Randomized Clinical Trial</dc:title>
<dc:type>info:eu-repo/semantics/article</dc:type>
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