2026-06-21T15:33:25Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/79942023-11-23T12:24:55Zcom_10259_4862com_10259_5086com_10259_2604col_10259_4863

Muñoz Moreno, Raquel Martínez Romero, Carles Blanco Melo, Daniel Forst, Christian V. Nachbagauer, Raffael Benitez, Asiel Arturo Mena, Ignacio Aslam, Sadaf Balasubramaniam, Vinod Lee, Ilseob Panis, Maryline Ayllón Barasoain, Juan Sachs, David Park, Man-Seong Krammer, Florian tenOever, Benjamin R. García Sastre, Adolfo 2023-11-10T13:46:28Z 2023-11-10T13:46:28Z 2019 2211-1247 http://hdl.handle.net/10259/7994 10.1016/j.celrep.2019.11.070 Influenza A viruses (IAVs) have a remarkable tropism in their ability to circulate in both mammalian and avian species. The IAV NS1 protein is a multifunctional virulence factor that inhibits the type I interferon host response through a myriad of mechanisms. How NS1 has evolved to enable this remarkable property across species and its specific impact in the overall replication, pathogenicity, and host preference remain unknown. Here we analyze the NS1 evolutionary landscape and host tropism using a barcoded library of recombinant IAVs. Results show a surprisingly great variety of NS1 phenotypes according to their ability to replicate in different hosts. The IAV NS1 genes appear to have taken diverse and random evolutionary pathways within their multiple phylogenetic lineages. In summary, the high evolutionary plasticity of this viral protein underscores the ability of IAVs to adapt to multiple hosts and aids in our understanding of its global prevalence. This research work was supported partially by CRIP (Center for Research on Influenza Pathogenesis), an NIH-NIAID-funded Center of Excellence for Influenza Research and Surveillance (CEIRS) (contract HHSN272201400008C), and by NIH-NIAID (grants U19AI117873 and U19AI135972). This research was also supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF), funded by the Ministry of Science and ICT of the Republic of Korea (NRF-2018M3A9H4056537 to M.-S.P., PI). application/pdf eng Cell Press Cell Reports. 2019, V. 29, n. 12, p. 3997-4009.e5 https://doi.org/10.1016/j.celrep.2019.11.070 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Influenza virus Orthomyxovirus NS1 evolution IFN response Innate immunity Barcoded library Medicina Salud Microbiología Genética Enfermedades infecciosas Medicine Health Microbiology Genetics Communicable diseases Viral Fitness Landscapes in Diverse Host Species Reveal Multiple Evolutionary Lines for the NS1 Gene of Influenza A Viruses info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Cell Reports 29 12 3997 4009.e5