2026-06-21T18:53:59Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/79942023-11-23T12:24:55Zcom_10259_4862com_10259_5086com_10259_2604col_10259_4863
Repositorio Institucional de la Universidad de Burgos
author
Muñoz Moreno, Raquel
author
Martínez Romero, Carles
author
Blanco Melo, Daniel
author
Forst, Christian V.
author
Nachbagauer, Raffael
author
Benitez, Asiel Arturo
author
Mena, Ignacio
author
Aslam, Sadaf
author
Balasubramaniam, Vinod
author
Lee, Ilseob
author
Panis, Maryline
author
Ayllón Barasoain, Juan
author
Sachs, David
author
Park, Man-Seong
author
Krammer, Florian
author
tenOever, Benjamin R.
author
García Sastre, Adolfo
2023-11-10T13:46:28Z
2023-11-10T13:46:28Z
2019
2211-1247
http://hdl.handle.net/10259/7994
10.1016/j.celrep.2019.11.070
Influenza A viruses (IAVs) have a remarkable tropism in their ability to circulate in both mammalian and avian species. The IAV NS1 protein is a multifunctional virulence factor that inhibits the type I interferon host response through a myriad of mechanisms. How NS1 has evolved to enable this remarkable property across species and its specific impact in the overall replication, pathogenicity, and host preference remain unknown. Here we analyze the NS1 evolutionary landscape and host tropism using a barcoded library of recombinant IAVs. Results show a surprisingly great variety of NS1 phenotypes according to their ability to replicate in different hosts. The IAV NS1 genes appear to have taken diverse and random evolutionary pathways within their multiple phylogenetic lineages. In summary, the high evolutionary plasticity of this viral protein underscores the ability of IAVs to adapt to multiple hosts and aids in our understanding of its global prevalence.
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Influenza virus
Orthomyxovirus
NS1 evolution
IFN response
Innate immunity
Barcoded library
Viral Fitness Landscapes in Diverse Host Species Reveal Multiple Evolutionary Lines for the NS1 Gene of Influenza A Viruses
info:eu-repo/semantics/article
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URL
https://riubu.ubu.es/bitstream/10259/7994/1/Mu%c3%b1oz-cr_2019.pdf
File
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Muñoz-cr_2019.pdf