2026-05-07T03:55:30Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/80502023-11-18T01:05:31Zcom_10259_5827com_10259_5086com_10259_2604col_10259_5828
Repositorio Institucional de la Universidad de Burgos
author
Martínez Álvarez, Jesús Román
author
López Jaen, Ana Belén
author
Cavia Saiz, Mónica
author
Muñiz Rodríguez, Pilar
author
Valls-Belles, Victoria
2023-11-17T13:20:06Z
2023-11-17T13:20:06Z
2023-07
http://hdl.handle.net/10259/8050
10.3390/antiox12071458
2076-3921
Olive oil and lycopene are foods that have potent antioxidant activity. The objective was
to determine the effects of consumption of olive oil enriched with lycopene on oxidative stress
biomarkers in hypercholesterolemic subjects. We examined the effects of oil enriched with lycopene
extract daily intake during 1 month on plasma antioxidant capacity, lipids profile (triacylgycerols, total
cholesterol, cHDL; cLDL, ox-LDL), biomarkers of oxidative stress, and inflammatory markers related
with atherosclerosis risk (C-reactive protein (CRP), IL-6; sDC4L) in subjects hypercholesteremics
(cholesterol > 220 mg/dL). In the group consuming olive oil-lycopene, significant increases (p < 0.05)
in the levels of plasma lycopene concentration (0.146 ± 0.03 versus 0.202 ± 0.04 (µmol/L)), α-carotene
(0.166 ± 0.064 versus 0.238 ± 0.07) and in β-carotene (0.493 ± 0.187 versus 0.713 ± 0.221) were
observed. These results are linked with the increases of plasma antioxidants and decreases biomarkers
of oxidative stress (carbonyl groups, malondialdehyde and 8-hydroxy-deoxiguanosine) observed
in hypercholesterolemic group. In relation to lipid profile, a significant decrease was observed
in the levels of ox-LDL (781 ± 302 versus 494 ± 200), remaining unchanged the levels of TG,
cholesterol, HDL and LDL-c. Regarding inflammatory biomarkers, the levels of CRP and IL-6
decreased significantly. The positive results obtained in this study support the use of olive oil
enriched with lycopene to reduce the risk of coronary disease.
eng
Atribución 4.0 Internacional
Lycopene
Olive oil
CRP
Cholesterol
Cytokines
Antioxidant capacity
Oxidative stress biomarkers
Beneficial Effects of Olive Oil Enriched with Lycopene on the Plasma Antioxidant and Anti-Inflammatory Profile of Hypercholesterolemic Patients
info:eu-repo/semantics/article
RWwgYXV0b3IgY29tbyDDum5pY28gdGl0dWxhciBkZSBsb3MgZGVyZWNob3MgZGUgcHJvcGllZGFkIGludGVsZWN0dWFsIGRlIGxhIG9icmEsIG8gZGlzcG9uaWVuZG8gZGUgbG9zIGRlYmlkb3MgcGVybWlzb3MgZGUgbG9zIG90cm9zIHRpdHVsYXJlcywgc2kgbG9zIGh1YmllcmEsIHkgZW4gdmlydHVkIGRlIGxvcyBkZXJlY2hvcyBxdWUgbGUgY29uZmllcmUgbGEgbGVnaXNsYWNpw7NuIHZpZ2VudGUgc29icmUgcHJvcGllZGFkIGludGVsZWN0dWFsIHkgZGVyZWNob3MgZGUgYXV0b3IsIA0KQVVUT1JJWkEgYSBsYSBVbml2ZXJzaWRhZCBkZSBCdXJnb3MgYSBkaWZ1bmRpciwgZGUgbWFuZXJhIGdyYXR1aXRhLCBlbCBjb250ZW5pZG8gZGUgbG9zIGFyY2hpdm9zIGRpZ2l0YWxlcyBxdWUgY29ycmVzcG9uZGVuIGFsIGRvY3VtZW50byBkZXNjcml0byBhbnRlcmlvcm1lbnRlLCBjb24gY2Fyw6FjdGVyIG5vIGV4Y2x1c2l2byB5IGRlIG1hbmVyYSBww7pibGljYSBlbiBhY2Nlc28gYWJpZXJ0byBhIHRyYXbDqXMgZGUgSW50ZXJuZXQsIHBhcmEgbG8gcXVlIGxhIEJpYmxpb3RlY2EgcHJvY2VkZXLDoSBhIGFyY2hpdmFybG9zIGVuIGVsIFJlcG9zaXRvcmlvIEluc3RpdHVjaW9uYWwuIEFzaW1pc21vIGF1dG9yaXphIGEgbGEgVW5pdmVyc2lkYWQgZGUgQnVyZ29zIGEgcmVhbGl6YXIgbGFzIHRyYW5zZm9ybWFjaW9uZXMgbmVjZXNhcmlhcyBkZSBmb3JtYXRvLCBubyBkZSBjb250ZW5pZG8sIHBhcmEgZ2FyYW50aXphciBsYSBwcmVzZXJ2YWNpw7NuIHkgZWwgYWNjZXNvIGVuIGVsIGZ1dHVyby4NCg0KRWwgYXV0b3IgZGlzcG9uZSwgZW4gdG9kbyBjYXNvLCBkZWwgZGVyZWNobyBhIHJldm9jYXIgZXN0YSBhdXRvcml6YWNpw7NuLg0KDQpMYSBjZXNpw7NuIGRlIGRlcmVjaG9zIGRlIGVzdGEgb2JyYSBzZSBlbmN1ZW50cmEgc3VqZXRhIGEgbGEgbGVnaXNsYWNpw7NuIHZpZ2VudGUgc29icmUgcHJvcGllZGFkIGludGVsZWN0dWFsIHkgZGVyZWNob3MgZGUgYXV0b3Iu
URL
https://riubu.ubu.es/bitstream/10259/8050/1/Mart%c3%adnez-antioxidants_2023.pdf
File
MD5
fdfa26b456916962c164a6f8b54a14b7
1203529
application/pdf
Martínez-antioxidants_2023.pdf