2026-04-22T09:20:24Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/80542023-11-20T08:57:24Zcom_10259_5827com_10259_5086com_10259_2604col_10259_5828

Gerardi, Gisela 229 500 0000-0003-2510-0422 Cavia Saiz, Mónica 116 600 0000-0001-5132-381X Rivero Pérez, Maria Dolores 473 600 0000-0003-0907-4009 González San José, Mª Luisa 258 600 0000-0003-2973-7287 Muñiz Rodríguez, Pilar 380 600 0000-0002-9306-0082 2023-11-17T13:53:11Z 2023-11-17T13:53:11Z 2019-07 1756-4646 1756-4646 http://hdl.handle.net/10259/8054 10.1016/j.jff.2019.05.003 Wine by-products show great potential as source of bioactive compounds that protect the vascular endothelial function by the modulation of both Nrf2 and Nf-κB pathways. This study investigates the pathways involved in the effects of a red wine pomace product (rWPP) against inflammatory and oxidative damage in hyperglycemic EA.hy926 endothelial cells. rWPP-digested fractions showed an inhibitory effect on IKK/IκBα/NF-κB pathway and a stimulatory effect on Akt-p38-MAPK/Nrf2 pathway with an impact on their antioxidant and anti-inflammatory downstream targets. In addition, the pathways regulation was also accompanied by downregulation of the gene expression of superoxide dismutase 2, cyclooxygenase 2 and NADPH oxidase 4. These results suggest the expression of SOD2 as an early adaptive response to the inflammatory effect mediated by NF-κB in hyperglycemic cells, and the treatment with the rWPP-digested fractions regulate this inflammatory process by Nrf2 pathway increased expression of antioxidant enzymes. The authors thank the financial support of the Autonomous Government of Castilla y León (Research project BU282U13). application/pdf spa Elsevier Journal of Functional Foods. 2019, V. 58, p. 255-265 https://doi.org/10.1016/j.jff.2019.05.003 info:eu-repo/grantAgreement/Junta de Castilla y León//BU282U13//APROVECHAMIENTO DE RESIDUOS DE VINIFICACIÓN: ESTUDIO DE SU EXPLOTACIÓN COMO INGREDIENTE FUNCIONAL Y ANÁLISIS DE LAS POSIBLES ALEGACIONES SALUDABLES/ Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Polyphenols Wine pomace Endothelial dysfunction NF-κB Nrf2 p38MAPK Akt SIRT1 Oxidative stress EA.hy926 Phase 2 enzymes SOD2 NOX4 COX2 Alimentos Bioquímica Biología molecular Food Biochemistry Molecular biology Modulation of Akt-p38-MAPK/Nrf2/SIRT1 and NF-κB pathways by wine pomace product in hyperglycemic endothelial cell line info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Journal of Functional Foods 58 255 265 THUMBNAIL Gerardi-jff_2019.pdf.jpg Gerardi-jff_2019.pdf.jpg IM Thumbnail image/jpeg 4245 https://riubu.ubu.es/bitstream/10259/8054/4/Gerardi-jff_2019.pdf.jpg bbb5747e7ec1b607d6362681820a9686 MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/8054/3/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 805 https://riubu.ubu.es/bitstream/10259/8054/2/license_rdf 4460e5956bc1d1639be9ae6146a50347 MD5 2 ORIGINAL Gerardi-jff_2019.pdf Gerardi-jff_2019.pdf application/pdf 1466634 https://riubu.ubu.es/bitstream/10259/8054/1/Gerardi-jff_2019.pdf 6a934fd4c6d71772118a2bac66e8ad66 MD5 1 10259/8054 oai:riubu.ubu.es:10259/8054 2023-11-20 09:57:24.571 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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