2026-07-10T04:14:57Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/85612025-01-22T10:17:59Zcom_10259_9895com_10259_3989com_10259.4_106com_10259_2604col_10259_9896

Abreu, Ana Cristina Morales Navas, Miguel Pérez Fernández, Cristian Sánchez Santed, Fernando Fernández, Ignacio 2024-02-02T12:45:43Z 2024-02-02T12:45:43Z 2021 1554-8929 http://hdl.handle.net/10259/8561 10.1021/ACSCHEMBIO.1C00053 1554-8937 NMR offers the unique potential to holistically screen hundreds of metabolites and has already proved to be a powerful technique able to provide a global picture of a wide range of metabolic processes underlying complex and multifactorial diseases, such as neurodegenerative and neurodevelopmental diseases. The aim of this study was to apply an NMR-based metabolomics approach to explore brain metabolic changes in both male and female rats induced by prenatal exposure to two chemicals associated with autism disorders—the organophosphorus pesticide chlorpyrifos (CPF) and the antiepileptic drug valproic acid (VPA)—at different postnatal ages. Depending on the age and on the brain region (hippocampus and cerebellum), several metabolites were shown to be significantly affected by exposure to both compounds. The evaluation of the spectral profiles revealed that the nervous-system-specific metabolite N-acetylaspartate (NAA), amino acid neurotransmitters (e.g., glutamate, glutamine, GABA, glycine), pyroglutamic acid, unsaturated fatty acids, and choline-based compounds are discriminant biomarkers. Additionally, metabolic changes varied as a function of age, but importantly not of sex. This research has been funded by the by the State Research Agency (projects RTC-2016-5239-2, CTQ2017-84334-R, and PSI2017-86847-C2-1-R) of the Spanish Ministry of Science, Innovation and Universities and EU FEDER funds. A.C.A. thanks University of Almería for a postdoctoral Hipatia fellowship. application/pdf eng American Chemical Society ACS Chemical Biology. 2021, V. 16, n. 4, p. 753-765 https://doi.org/10.1021/ACSCHEMBIO.1C00053 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Fisiología Química física Psicología Salud Physiology Chemistry, Physical and theoretical Psychology Health NMR-Based Metabolomics Approach to Explore Brain Metabolic Changes Induced by Prenatal Exposure to Autism-Inducing Chemicals info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion ACS Chemical Biology 16 4 753 765