2026-04-19T16:46:36Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/86092024-02-08T01:05:34Zcom_10259_3592com_10259_3591com_10259.4_106com_10259_2604com_10259_3924com_10259_5086col_10259_3930col_10259_3925

Alonso Carrillo, Daniel Carreira Barral, Israel Mielczarek, Marcin Sancho Medina, Andrea Herran, Enara Vairo, Claudia Pozo, Ángel del Luzuriaga, Iris Lazcanoiturburu, Nerea Ibarrola, Oihane Ponce, Sara Villar Vidal, María García Valverde, María Quesada Pato, Roberto 2024-02-07T08:07:42Z 2024-02-07T08:07:42Z 2023-08 1477-0520 http://hdl.handle.net/10259/8609 10.1039/D3OB01182H 1477-0539 Six novel click-tambjamines (1–6) bearing an alkyl chain of varying length linked to the imine moiety have been formulated in nanostructured lipid carriers (NLCs) to evaluate their transmembrane anion transport activity both when free (i.e., not encapsulated) and nanoformulated. Nanostructured lipid carriers (NLCs) are an example of drug delivery systems (DDSs) that stand out because of their versatility. In this work we show that NLCs can be used to efficiently formulate highly lipophilic anionophores and experiments conducted in model liposomes reveal that these formulations are adequate to deliver anionophores without compromising their transport activity. This result paves the way to facilitate the study of highly lipophilic anionophores and their potential use as future drugs. This research has been financially supported by Consejería de Educación de la Junta de Castilla y León and European Regional Development Fund (ERDF) (project BU067P20), Ministerio de Ciencia e Innovación (project PID2020-117610RB-I00), Gobierno Vasco (Elkartek program 2021 KK-2021/00052), and Alava Innova program 2021 (INNOAS-2021/00003) of the Provincial Council of Alava. D. A.-C. and I. C.-B. thank Consejería de Educación de la Junta de Castilla y León, ERDF and European Social Fund (ESF) for their pre-doctoral and post-doctoral contracts, respectively. application/pdf eng Royal Society of Chemistry Organic & Biomolecular Chemistry. 2023, V. 21, n. 38, p. 7753-7757 https://doi.org/10.1039/D3OB01182H Attribution-NonCommercial 3.0 Unported http://creativecommons.org/licenses/by-nc/3.0/ info:eu-repo/semantics/openAccess Química orgánica Bioquímica Chemistry, Organic Biochemistry Formulation and evaluation of anion transporters in nanostructured lipid carriers info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Organic & Biomolecular Chemistry 21 38 7753 7757