2026-04-19T09:33:00Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/86092024-02-08T01:05:34Zcom_10259_3592com_10259_3591com_10259.4_106com_10259_2604com_10259_3924com_10259_5086col_10259_3930col_10259_3925
Alonso Carrillo, Daniel
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600
0000-0002-6132-8953
Carreira Barral, Israel
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600
0000-0002-4835-8752
Mielczarek, Marcin
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600
Sancho Medina, Andrea
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Herran, Enara
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Vairo, Claudia
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Pozo, Ángel del
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Luzuriaga, Iris
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Lazcanoiturburu, Nerea
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Ibarrola, Oihane
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Ponce, Sara
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Villar Vidal, María
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García Valverde, María
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0000-0002-3990-8388
Quesada Pato, Roberto
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0000-0003-2764-7157
2024-02-07T08:07:42Z
2024-02-07T08:07:42Z
2023-08
1477-0520
http://hdl.handle.net/10259/8609
10.1039/D3OB01182H
1477-0539
Six novel click-tambjamines (1–6) bearing an alkyl chain of varying length linked to the imine moiety have been formulated in nanostructured lipid carriers (NLCs) to evaluate their transmembrane anion transport activity both when free (i.e., not encapsulated) and nanoformulated. Nanostructured lipid carriers (NLCs) are an example of drug delivery systems (DDSs) that stand out because of their versatility. In this work we show that NLCs can be used to efficiently formulate highly lipophilic anionophores and experiments conducted in model liposomes reveal that these formulations are adequate to deliver anionophores without compromising their transport activity. This result paves the way to facilitate the study of highly lipophilic anionophores and their potential use as future drugs.
This research has been financially supported by Consejería de Educación de la Junta de Castilla y León and European Regional Development Fund (ERDF) (project BU067P20), Ministerio de Ciencia e Innovación (project PID2020-117610RB-I00), Gobierno Vasco (Elkartek program 2021 KK-2021/00052), and Alava Innova program 2021 (INNOAS-2021/00003) of the Provincial Council of Alava. D. A.-C. and I. C.-B. thank Consejería de Educación de la Junta de Castilla y León, ERDF and European Social Fund (ESF) for their pre-doctoral and post-doctoral contracts, respectively.
application/pdf
eng
Royal Society of Chemistry
Organic & Biomolecular Chemistry. 2023, V. 21, n. 38, p. 7753-7757
https://doi.org/10.1039/D3OB01182H
Attribution-NonCommercial 3.0 Unported
http://creativecommons.org/licenses/by-nc/3.0/
info:eu-repo/semantics/openAccess
Química orgánica
Bioquímica
Chemistry, Organic
Biochemistry
Formulation and evaluation of anion transporters in nanostructured lipid carriers
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Organic & Biomolecular Chemistry
21
38
7753
7757
THUMBNAIL
Alonso_rsc_2023.pdf.jpg
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LICENSE
license.txt
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Alonso_rsc_2023.pdf
Alonso_rsc_2023.pdf
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10259/8609
oai:riubu.ubu.es:10259/8609
2024-02-08 02:05:34.969
Repositorio Institucional de la Universidad de Burgos
bubrep@ubu.es
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