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oai:riubu.ubu.es:10259/86132024-02-08T01:05:24Zcom_10259_3592com_10259_3591com_10259.4_106com_10259_2604com_10259_3924com_10259_5086col_10259_3930col_10259_3925

Keto-Enol Tautomerism in Passerini and Ugi Adducts Pertejo Fernández, Pablo Sancho Medina, Andrea Hermosilla, Tomás González Saiz, Beatriz Gómez Ayuso, Javier Quesada Pato, Roberto Moreno Mediavilla, Daniel Carreira Barral, Israel García Valverde, María Keto-enol tautomerism Passerini adduct Ugi adduct Lactone Lactame 2-hydroxyglutaric acid Química orgánica Chemistry, Organic The use of arylglyoxal as starting material in Passerini and Ugi reactions affords βketoamides. This has allowed to study keto-enol tautomerism in these systems and assess the way in which the presence of acyloxy or aminoacyl groups bound to the C2 position affects such tautomerism, and to investigate the reactivity of both the enol and carbonyl forms. In this work we also prove the versatility of the Passerini reaction, since depending on the conditions to which the corresponding adducts are subjected different products of synthetic interest can be obtained. This research was funded by Consejería de Educación de la Junta de Castilla y León, project BU075G19. 2024-02-07T09:07:18Z 2024-02-07T09:07:18Z 2021-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/10259/8613 10.3390/molecules26040919 1420-3049 eng Molecules. 2021, V. 26, n. 4, 919 https://doi.org/10.3390/molecules26040919 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf MDPI