2026-11-02T19:18:11Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/86312024-02-09T01:05:25Zcom_10259_6256com_10259_5086com_10259_2604col_10259_6257
Castaño Castaño, Sergio
Martínez Navarrete, Gema
Morales Navas, Miguel
Fernández Jover, Eduardo
Sánchez Santed, Fernando
Nieto Escámez, Francisco A.
2024-02-08T11:07:27Z
2024-02-08T11:07:27Z
2019-02
0006-8993
http://hdl.handle.net/10259/8631
10.1016/j.brainres.2018.09.039
In this work visual functional improvement of amblyopic Long Evans rats treated with tDCS has been assessed
using the “slow angled-descent forepaw grasping” (SLAG) test. This test is based on an innate response that does
not requires any memory-learning component and has been used before for measuring visual function in rodents.
The results obtained show that this procedure is useful to assess monocular but not binocular deficits, as controls
and amblyopic animals showed significant differences during monocular but not during binocular assessment.
On the other hand, parvoalbumin labelling was analysed in three areas of the visual cortex (V1M, V1B and V2L)
before and after tDCS treatment. No changes in labelling were observed after monocular deprivation. However,
tDCS treatment significantly improved vision through the amblyopic eye, and a significant increase of parvoalbumin-positive cells was observed in the three areas, both in the stimulated hemisphere but also in the nonstimulated hemisphere. This effect occurred both in control and amblyopic animals. Thus, tDCS induced changes
are similar in controls and amblyopic animals, although only the last one showed a functional improvement.
This research was supported by research grants PS09-01163, from FIS, and PSI2014-55785-C2-1-R, from MINECO and EU FEDER funds.
application/pdf
eng
Elsevier
Brain Research. 2019, V. 1704, p. 94-102
https://doi.org/10.1016/j.brainres.2018.09.039
Amblyopia
tDCS
GABA
Parvoalbumin
SLAG
Salud
Ensayos (Tecnología)
Fisiología
Biología molecular
Health
Testing
Physiology
Molecular biology
Transcranial direct-current stimulation (tDCS) improves detection of simple bright stimuli by amblyopic Long Evans rats in the SLAG task and produces an increase of parvoalbumin labelled cells in visual cortices
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/closedAccess
Brain Research
1704
94
102