2026-04-19T09:33:15Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/86312024-02-09T01:05:25Zcom_10259_6256com_10259_5086com_10259_2604col_10259_6257

Castaño Castaño, Sergio e3e1c1b0-6bce-4b28-90d2-4a63e01e6f75 600 Martínez Navarrete, Gema e457a370-3b75-497f-a611-ed0eb2bd0975 600 Morales Navas, Miguel ff319719-8f20-4c73-ac94-48123f9ddb66 600 Fernández Jover, Eduardo 832ac52d-c421-42b9-8002-95a99aba6adb 600 Sánchez Santed, Fernando 3945434c-d67b-4d35-8c6d-262ce027f039 600 Nieto Escámez, Francisco A. 2d0d4edc-1ae7-44a0-8f5c-003b48190c98 600 2024-02-08T11:07:27Z 2024-02-08T11:07:27Z 2019-02 0006-8993 http://hdl.handle.net/10259/8631 10.1016/j.brainres.2018.09.039 In this work visual functional improvement of amblyopic Long Evans rats treated with tDCS has been assessed using the “slow angled-descent forepaw grasping” (SLAG) test. This test is based on an innate response that does not requires any memory-learning component and has been used before for measuring visual function in rodents. The results obtained show that this procedure is useful to assess monocular but not binocular deficits, as controls and amblyopic animals showed significant differences during monocular but not during binocular assessment. On the other hand, parvoalbumin labelling was analysed in three areas of the visual cortex (V1M, V1B and V2L) before and after tDCS treatment. No changes in labelling were observed after monocular deprivation. However, tDCS treatment significantly improved vision through the amblyopic eye, and a significant increase of parvoalbumin-positive cells was observed in the three areas, both in the stimulated hemisphere but also in the nonstimulated hemisphere. This effect occurred both in control and amblyopic animals. Thus, tDCS induced changes are similar in controls and amblyopic animals, although only the last one showed a functional improvement. This research was supported by research grants PS09-01163, from FIS, and PSI2014-55785-C2-1-R, from MINECO and EU FEDER funds. application/pdf eng Elsevier Brain Research. 2019, V. 1704, p. 94-102 https://doi.org/10.1016/j.brainres.2018.09.039 Amblyopia tDCS GABA Parvoalbumin SLAG Salud Ensayos (Tecnología) Fisiología Biología molecular Health Testing Physiology Molecular biology Transcranial direct-current stimulation (tDCS) improves detection of simple bright stimuli by amblyopic Long Evans rats in the SLAG task and produces an increase of parvoalbumin labelled cells in visual cortices info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/closedAccess Brain Research 1704 94 102 THUMBNAIL Castaño-br_2019.pdf.jpg Castaño-br_2019.pdf.jpg IM Thumbnail image/jpeg 3392 https://riubu.ubu.es/bitstream/10259/8631/3/Casta%c3%b1o-br_2019.pdf.jpg 4df78529f5138c064b23415858abd8ce MD5 3 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/8631/2/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 2 ORIGINAL Castaño-br_2019.pdf Castaño-br_2019.pdf Archivo cerrado application/pdf 2468747 https://riubu.ubu.es/bitstream/10259/8631/1/Casta%c3%b1o-br_2019.pdf e9dd1c80e9388a140aaa1db8bf3fe36a MD5 1 10259/8631 oai:riubu.ubu.es:10259/8631 2024-02-09 02:05:25.884 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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