2026-04-20T01:52:24Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/86542024-02-10T01:05:35Zcom_10259_6256com_10259_5086com_10259_2604col_10259_6257

Castaño Castaño, Sergio e3e1c1b0-6bce-4b28-90d2-4a63e01e6f75 600 Garcia-Moll, A. 895727ea-36cc-4862-9825-fb04e069b97a Morales Navas, Miguel ff319719-8f20-4c73-ac94-48123f9ddb66 600 Fernández Jover, Eduardo 832ac52d-c421-42b9-8002-95a99aba6adb 600 Sánchez Santed, Fernando 3945434c-d67b-4d35-8c6d-262ce027f039 600 Nieto Escámez, Francisco A. 2d0d4edc-1ae7-44a0-8f5c-003b48190c98 600 2024-02-09T10:38:27Z 2024-02-09T10:38:27Z 2017-02 0006-8993 http://hdl.handle.net/10259/8654 10.1016/j.brainres.2017.01.003 Transcranial direct current stimulation (tDCS) has proved to increase brain cortex plasticity and different models of brain damage. In this work, we have analyzed the effects of tDCS in an experimental model of amblyopia using Long-Evans rats. Animals were monocularly deprived between 12 and 75 postnatal days and visual cortex contralateral to the deprived eye was stimulated using anodal tDCS during 8 days (20 min/day). The effects of tDCS treatment on the visual function were evaluated by using the optomotor reflex of the animals as a measure of visual acuity. Results obtained indicate that monocular occlusion during the critical period lead to a reduction of visual acuity in monocular and binocular conditions. Stimulation with anodal tDCS produced a nearly full recovery in visual acuity of amblyopic animals. However, same stimulation protocol in healthy control animals produced a decrease of binocular visual acuity. These data indicate that tDCS can reverse the effects of monocular deprivation on visual acuity, although it is essential to use this technique in a controlled way due to the possible adverse effects on healthy individuals. This research was supported by research Grants PS09-01163 from Fondo de Investigación en Salud (FIS), and PSI2014-55785-C2-1-R from MINECO and EU FEDER funds. We want to thank Prof. Antonio Fimia from University Miguel Hernández for his advice and helpful commentaries about the visual acuity assessment parameters and analysis procedure in Argos. application/pdf eng Elsevier Brain Research. 2017, V. 1657, p. 340-346 https://doi.org/10.1016/j.brainres.2017.01.003 Visual deprivation Optomotor reflex Visual acuity Amblyopia tDCS Fisiología Biología molecular Salud Medicina Physiology Molecular biology Health Medicine Transcranial direct current stimulation improves visual acuity in amblyopic Long-Evans rats info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/closedAccess Brain Research 1657 340 346 THUMBNAIL Castaño-br_2017.pdf.jpg Castaño-br_2017.pdf.jpg IM Thumbnail image/jpeg 4917 https://riubu.ubu.es/bitstream/10259/8654/3/Casta%c3%b1o-br_2017.pdf.jpg fc5d4049e546c03312efea4a5c1442db MD5 3 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/8654/2/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 2 ORIGINAL Castaño-br_2017.pdf Castaño-br_2017.pdf Archivo cerrado application/pdf 857648 https://riubu.ubu.es/bitstream/10259/8654/1/Casta%c3%b1o-br_2017.pdf bf2f951a8e19cd8006823aa79b5ea321 MD5 1 10259/8654 oai:riubu.ubu.es:10259/8654 2024-02-10 02:05:35.743 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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