2026-06-01T18:43:20Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/87752024-03-08T01:05:25Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220

Jiménez Jiménez, Félix Javier García Martín, Elena Alonso Navarro, Hortensia Martínez, Carmen Zurdo, Martín Turpín Fenoll, Laura Millán Pascual, Jorge Adeva Bartolomé, Teresa Cubo Delgado, Esther Navacerrada, Francisco Rojo Sebastián, Ana Rubio, Lluisa Ortega Cubero, Sara Pastor, Pau Calleja, Marisol Plaza Nieto, José Francisco Pilo de la Fuente, Belén Arroyo Solera, Margarita García Albea, Esteban Agúndez, José A. G. 2024-03-07T12:20:31Z 2024-03-07T12:20:31Z 2015-11 0025-7974 http://hdl.handle.net/10259/8775 10.1097/MD.0000000000002125 Several recent works suggest a possible role of vitamin D deficiency in the etiology or restless legs syndrome (RLS). We analyzed the possible relationship of 2 common single nucleotide polymorphisms (SNPs) in the vitamin D3 receptor (VDR) gene with the risk for RLS. We studied the genotype and allelic variant frequencies of VDR rs2228570 and VDR rs731236 SNPs in 205 RLS patients and 445 healthy controls using a TaqMan essay. The frequencies of the rs731236AA genotype and the allelic variant rs731236A were significantly lower in RLS patients than in controls (P < 0.005 and < 0.01, respectively). Restless legs syndrome patients carrying the allelic variant rs731236G had an earlier age at onset, and those carrying the rs731236GG genotype had higher severity of RLS, although these data disappeared after multivariate analyses. None of the SNPs studied was related with the positivity of family history of RLS. These results suggest a modest, but significant association between VDR rs731236 SNP and the risk for RLS. This work was supported in part by Grants PI12/00241, PI12/00324, and RETICS RD12/0013/0002 from Fondo de Investigacio´n Sanitaria, Instituto de Salud Carlos III, Madrid, Spain, and GR15026 from Junta de Extremadura, Me´rida, Spain, and PRIS10016 (Fundesalud, Me´rida,Spain), and by grants from the Spanish Ministry of Science and Innovation SAF2006-10126 (2006–2009) and SAF2010-22329-C02-01 (2011- 2013) to PP and by the ‘‘Unio´n Te´cnica de Empresas’’ (UTE) project FIMA to PP and project from the Centro de Investigaciones Me´dicas Aplicadas (CIMA), Spain. Partially funded with FEDER funds. application/pdf eng Wolters Kluwer Health Medicine. 2014, V. 94, n. 47, e2125 https://journals.lww.com/md-journal/fulltext/2015/11240/association_between_vitamin_d_receptor_rs731236.57.aspx Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Sistema nervioso-Enfermedades Medicina Nervous system-Diseases Medicine Association Between Vitamin D Receptor rs731236 (Taq1) Polymorphism and Risk for Restless Legs Syndrome in the Spanish Caucasian Population info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Medicine 94 47