2026-05-07T09:28:54Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/87752024-03-08T01:05:25Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220

00925njm 22002777a 4500 dc Jiménez Jiménez, Félix Javier author García Martín, Elena author Alonso Navarro, Hortensia author Martínez, Carmen author Zurdo, Martín author Turpín Fenoll, Laura author Millán Pascual, Jorge author Adeva Bartolomé, Teresa author Cubo Delgado, Esther author Navacerrada, Francisco author Rojo Sebastián, Ana author Rubio, Lluisa author Ortega Cubero, Sara author Pastor, Pau author Calleja, Marisol author Plaza Nieto, José Francisco author Pilo de la Fuente, Belén author Arroyo Solera, Margarita author García Albea, Esteban author Agúndez, José A. G. author 2015-11 Several recent works suggest a possible role of vitamin D deficiency in the etiology or restless legs syndrome (RLS). We analyzed the possible relationship of 2 common single nucleotide polymorphisms (SNPs) in the vitamin D3 receptor (VDR) gene with the risk for RLS. We studied the genotype and allelic variant frequencies of VDR rs2228570 and VDR rs731236 SNPs in 205 RLS patients and 445 healthy controls using a TaqMan essay. The frequencies of the rs731236AA genotype and the allelic variant rs731236A were significantly lower in RLS patients than in controls (P < 0.005 and < 0.01, respectively). Restless legs syndrome patients carrying the allelic variant rs731236G had an earlier age at onset, and those carrying the rs731236GG genotype had higher severity of RLS, although these data disappeared after multivariate analyses. None of the SNPs studied was related with the positivity of family history of RLS. These results suggest a modest, but significant association between VDR rs731236 SNP and the risk for RLS. 0025-7974 http://hdl.handle.net/10259/8775 10.1097/MD.0000000000002125 Association Between Vitamin D Receptor rs731236 (Taq1) Polymorphism and Risk for Restless Legs Syndrome in the Spanish Caucasian Population