2026-06-10T15:29:29Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/87872024-03-09T01:05:22Zcom_10259_6688com_10259_5086com_10259_2604com_10259_4219col_10259_6689col_10259_4220
Repositorio Institucional de la Universidad de Burgos
author
Cubo Delgado, Esther
author
Gallego Nieto, César
author
Elizari Roncal, Miren
author
Barroso Pérez, Mª Teresa
author
Collazo Riobó, Carla
author
Delgado López, Pedro David
2024-03-08T12:47:10Z
2024-03-08T12:47:10Z
2019-07
http://hdl.handle.net/10259/8787
10.5334/tohm.508
2160-8288
Background: Restless legs syndrome (RLS) is a common sleep disorder,. although controversial, growing evidence relates the presence of RLS to an increased risk of mortality, mainly due to cardiovascular events. The aim of this article was to review the role of RLS as a risk factor of mortality according to independent cohort studies.
Methods: We performed a literature review via PubMed database for articles relating RLS and mortality. We used the random-effects model to calculate the pooled effect estimates on mortality. Heterogeneity between studies was assessed using quantitative and qualitative analysis.
Results: Out of 100 articles identified, 13 were finally included. Although studies were heterogeneous (p = 0.001), no significant publication bias was found. When all cohort studies were considered, the random-effects model yielded a significantly increased risk of mortality in RLS versus non-RLS patients (13 studies, hazard ratio [HR] = 1.52, 95% confidence interval [CI] 1.28–1.80). However, this association was not statistically significant when only cohort studies using the international RLS diagnostic criteria were considered (5 studies, HR = 1.63, 95% CI 0.94–2.81).
Discussion: The results of this meta-analysis suggest that RLS seems to be a risk factor of mortality, although this association is conditioned by the diagnostic criteria used in the studies. Future long-term follow-up standardized mortality studies are needed to address this important question that carries potential impact on population global health.
eng
Attribution-NonCommercial-NoDerivs 3.0 Unported
Restless legs syndrome
Mortality
Survival
Epidemiology
Cohorts
Sleep disorder
Is Restless Legs Syndrome Associated with an Increased Risk of Mortality? A Meta-Analysis of Cohort Studies
info:eu-repo/semantics/article
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URL
https://riubu.ubu.es/bitstream/10259/8787/1/Cubo-tohm_2019.pdf
File
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dff053e806ada7557d39277a9b6d7121
1216760
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Cubo-tohm_2019.pdf