2026-08-19T09:28:16Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/87932024-03-12T01:05:26Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220

Jesús, Silvia Labrador Espinosa, Miguel A. Adarmes Gómez, Astrid D. Méndel del Barrio, C. Martínez Castrillo, Juan Carlos Alonso Cánovas, Araceli Sánchez Alonso, Pilar Novo Pontes, Sabela Alonso Losada, María Gema López Ariztegui, Nuria Segundo Rodríguez, José Clemente Morales, M. I. Gastón, Itziar Lacruz Bescos, F. Clavero Ibarra, Pedro Kulisevsky Bojarsky, Jaume Pagonabarraga, Javier Pascual Sedano, Berta Martínez Martín, Pablo Santos García, Diego Mir, Pablo Cubo Delgado, Esther COPPADIS Study Group 2024-03-11T10:34:07Z 2024-03-11T10:34:07Z 2020-10 http://hdl.handle.net/10259/8793 10.1038/s41598-020-73756-z 2045-2322 The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson’s disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) for ICD/CB screening. The association between demographic data and ICDs/CBs was analyzed in both groups. In PD, this relationship was evaluated using clinical features and treatment-related data. As result, 613 PD patients (mean age 62.47 ± 9.09 years, 59.87% men) and 179 CS (mean age 60.84 ± 8.33 years, 47.48% men) were included. ICDs and CBs were more frequent in PD (ICDs 12.7% vs. 1.6%, p < 0.001; CBs 7.18% vs. 1.67%, p = 0.01). PD patients had more frequent previous ICDs history, premorbid impulsive personality and antidepressant treatment (p < 0.05) compared with CS. In PD, patients with ICDs/CBs presented younger age at disease onset, more frequent history of previous ICDs and premorbid personality (p < 0.05), as well as higher comorbidity with nonmotor symptoms, including depression and poor quality of life. Treatment with dopamine agonists increased the risk of ICDs/CBs, being dose dependent (p < 0.05). As conclusions, ICDs and CBs were more frequent in patients with PD than in CS. More nonmotor symptoms were present in patients with PD who had ICDs/CBs compared with those without. Dopamine agonists have a prominent effect on ICDs/CBs, which could be influenced by dose. application/pdf eng Springer Nature Scientific Reports. 2020, V. 10, n. 1 https://doi.org/10.1038/s41598-020-73756-z Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Sistema nervioso-Enfermedades Medicina Neurología Nervous system-Diseases Medicine Neurology Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Scientific Reports 10 1