2026-08-19T09:29:36Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/87932024-03-12T01:05:26Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220

00925njm 22002777a 4500 dc Jesús, Silvia author Labrador Espinosa, Miguel A. author Adarmes Gómez, Astrid D. author Méndel del Barrio, C. author Martínez Castrillo, Juan Carlos author Alonso Cánovas, Araceli author Sánchez Alonso, Pilar author Novo Pontes, Sabela author Alonso Losada, María Gema author López Ariztegui, Nuria author Segundo Rodríguez, José Clemente author Morales, M. I. author Gastón, Itziar author Lacruz Bescos, F. author Clavero Ibarra, Pedro author Kulisevsky Bojarsky, Jaume author Pagonabarraga, Javier author Pascual Sedano, Berta author Martínez Martín, Pablo author Santos García, Diego author Mir, Pablo author Cubo Delgado, Esther author COPPADIS Study Group author 2020-10 The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson’s disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) for ICD/CB screening. The association between demographic data and ICDs/CBs was analyzed in both groups. In PD, this relationship was evaluated using clinical features and treatment-related data. As result, 613 PD patients (mean age 62.47 ± 9.09 years, 59.87% men) and 179 CS (mean age 60.84 ± 8.33 years, 47.48% men) were included. ICDs and CBs were more frequent in PD (ICDs 12.7% vs. 1.6%, p < 0.001; CBs 7.18% vs. 1.67%, p = 0.01). PD patients had more frequent previous ICDs history, premorbid impulsive personality and antidepressant treatment (p < 0.05) compared with CS. In PD, patients with ICDs/CBs presented younger age at disease onset, more frequent history of previous ICDs and premorbid personality (p < 0.05), as well as higher comorbidity with nonmotor symptoms, including depression and poor quality of life. Treatment with dopamine agonists increased the risk of ICDs/CBs, being dose dependent (p < 0.05). As conclusions, ICDs and CBs were more frequent in patients with PD than in CS. More nonmotor symptoms were present in patients with PD who had ICDs/CBs compared with those without. Dopamine agonists have a prominent effect on ICDs/CBs, which could be influenced by dose. http://hdl.handle.net/10259/8793 10.1038/s41598-020-73756-z 2045-2322 Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort