2026-06-17T20:49:50Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/88032024-03-13T01:05:30Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220

Santos García, Diego Suárez Castro, Ester Deus-Fonticoba, Teresa de Feal Panceiras, M. J. Muñoz Enríquez, J. G. Paz González, José Manuel Cores Bartolomé, Carlos Planellás, Lluis L. García Caldentey, Juan Caballol, Núria Legarda, Inés Cabo López, Iria López Manzanares, Lydia Ávila Rivera, María A. Catalán, María José Nogueira, Víctor Borrue, Carmen Álvarez Saúco, María Vela Desojo, Lydia Cubo Delgado, Esther Martínez Castrillo, Juan Carlos Sánchez Alonso, Pilar Alonso Losada, María Gema López Ariztegui, Nuria Gastón, Itziar Kulisevsky Bojarsky, Jaume Pagonabarraga, Javier Seijo, Manuel Ruíz Martínez, Javier Valero, Caridad Kurtis, Mónica M. González Ardura, Jessica Prieto, Cristina Mir, Pablo Martínez Martín, Pablo COPPADIS Study Group 2020-10 Introduction: The aim of the present study was to examine the frequency of self-reported sleep problems and their associated factors in a large cohort of PD patients. Methods: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort were included in this cross-sectional study. Sleep problems were assessed by the Spanish version of the Parkinson’s disease Sleep Scale version 1 (PDSS-1). An overall score below 82 or a score below 5 on at least 1 item was defined as sleep problems. Results: The frequency of sleep problems was nearly double in PD patients compared to controls: 65.8% (448/681) vs 33.5% (65/206) (p < 0.0001). Mean total PDSS score was lower in PD patients than controls: 114.9 ± 28.8 vs 132.8 ± 16.3 (p < 0.0001). Quality of life (QoL) was worse in PD patients with sleep problems compared to those without: PDQ-39SI, 19.3 ± 14 vs 13 ± 11.6 (p < 0.0001); EUROHIS-QoL8, 3.7 ± 0.5 vs 3.9 ± 0.5 (p < 0.0001). Non-motor symptoms burden (NMSS; OR = 1.029; 95%CI 1.015–1.043; p < 0.0001) and impulse control behaviors (QUIP-RS; OR = 1.054; 95%CI 1.009–1.101; p = 0.018) were associated with sleep problems after adjustment for age, gender, disease duration, daily equivalent levodopa dose, H&Y, UPDRS-III, UPDRS-IV, PD-CRS, BDI-II, NPI, VAS-Pain, VAFS, FOGQ, and total number of non-antiparkinsonian treatments. Conclusion: Sleep problems were frequent in PD patients and were related to both a worse QoL and a greater non-motor symptoms burden in PD. These findings call for increased awareness of sleep problems in PD patients. application/pdf http://hdl.handle.net/10259/8803 eng SAGE Publications Sleep Problems Are Related to a Worse Quality of Life and a Greater Non-Motor Symptoms Burden in Parkinson’s Disease info:eu-repo/semantics/article TEXT RIUBU. Repositorio Institucional de la Universidad de Burgos Hispana