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00925njm 22002777a 4500 dc Santos García, Diego author Suárez Castro, Ester author Deus-Fonticoba, Teresa de author Feal Panceiras, M. J. author Muñoz Enríquez, J. G. author Paz González, José Manuel author Cores Bartolomé, Carlos author Planellás, Lluis L. author García Caldentey, Juan author Caballol, Núria author Legarda, Inés author Cabo López, Iria author López Manzanares, Lydia author Ávila Rivera, María A. author Catalán, María José author Nogueira, Víctor author Borrue, Carmen author Álvarez Saúco, María author Vela Desojo, Lydia author Cubo Delgado, Esther author Martínez Castrillo, Juan Carlos author Sánchez Alonso, Pilar author Alonso Losada, María Gema author López Ariztegui, Nuria author Gastón, Itziar author Kulisevsky Bojarsky, Jaume author Pagonabarraga, Javier author Seijo, Manuel author Ruíz Martínez, Javier author Valero, Caridad author Kurtis, Mónica M. author González Ardura, Jessica author Prieto, Cristina author Mir, Pablo author Martínez Martín, Pablo author COPPADIS Study Group author 2020-10 Introduction: The aim of the present study was to examine the frequency of self-reported sleep problems and their associated factors in a large cohort of PD patients. Methods: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort were included in this cross-sectional study. Sleep problems were assessed by the Spanish version of the Parkinson’s disease Sleep Scale version 1 (PDSS-1). An overall score below 82 or a score below 5 on at least 1 item was defined as sleep problems. Results: The frequency of sleep problems was nearly double in PD patients compared to controls: 65.8% (448/681) vs 33.5% (65/206) (p < 0.0001). Mean total PDSS score was lower in PD patients than controls: 114.9 ± 28.8 vs 132.8 ± 16.3 (p < 0.0001). Quality of life (QoL) was worse in PD patients with sleep problems compared to those without: PDQ-39SI, 19.3 ± 14 vs 13 ± 11.6 (p < 0.0001); EUROHIS-QoL8, 3.7 ± 0.5 vs 3.9 ± 0.5 (p < 0.0001). Non-motor symptoms burden (NMSS; OR = 1.029; 95%CI 1.015–1.043; p < 0.0001) and impulse control behaviors (QUIP-RS; OR = 1.054; 95%CI 1.009–1.101; p = 0.018) were associated with sleep problems after adjustment for age, gender, disease duration, daily equivalent levodopa dose, H&Y, UPDRS-III, UPDRS-IV, PD-CRS, BDI-II, NPI, VAS-Pain, VAFS, FOGQ, and total number of non-antiparkinsonian treatments. Conclusion: Sleep problems were frequent in PD patients and were related to both a worse QoL and a greater non-motor symptoms burden in PD. These findings call for increased awareness of sleep problems in PD patients. 0891-9887 http://hdl.handle.net/10259/8803 10.1177/0891988720964250 1552-5708 Non-motor symptoms Parkinson’s disease Parkinson’s disease sleep scale Quality of life Sleep Sleep Problems Are Related to a Worse Quality of Life and a Greater Non-Motor Symptoms Burden in Parkinson’s Disease