2026-08-19T10:53:42Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/88032024-03-13T01:05:30Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220
Santos García, Diego
Suárez Castro, Ester
Deus-Fonticoba, Teresa de
Feal Panceiras, M. J.
Muñoz Enríquez, J. G.
Paz González, José Manuel
Cores Bartolomé, Carlos
Planellás, Lluis L.
García Caldentey, Juan
Caballol, Núria
Legarda, Inés
Cabo López, Iria
López Manzanares, Lydia
Ávila Rivera, María A.
Catalán, María José
Nogueira, Víctor
Borrue, Carmen
Álvarez Saúco, María
Vela Desojo, Lydia
Cubo Delgado, Esther
Martínez Castrillo, Juan Carlos
Sánchez Alonso, Pilar
Alonso Losada, María Gema
López Ariztegui, Nuria
Gastón, Itziar
Kulisevsky Bojarsky, Jaume
Pagonabarraga, Javier
Seijo, Manuel
Ruíz Martínez, Javier
Valero, Caridad
Kurtis, Mónica M.
González Ardura, Jessica
Prieto, Cristina
Mir, Pablo
Martínez Martín, Pablo
COPPADIS Study Group
2024-03-12T08:29:39Z
2024-03-12T08:29:39Z
2020-10
0891-9887
http://hdl.handle.net/10259/8803
10.1177/0891988720964250
1552-5708
Introduction:
The aim of the present study was to examine the frequency of self-reported sleep problems and their associated factors in a large cohort of PD patients.
Methods:
PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort were included in this cross-sectional study. Sleep problems were assessed by the Spanish version of the Parkinson’s disease Sleep Scale version 1 (PDSS-1). An overall score below 82 or a score below 5 on at least 1 item was defined as sleep problems.
Results:
The frequency of sleep problems was nearly double in PD patients compared to controls: 65.8% (448/681) vs 33.5% (65/206) (p < 0.0001). Mean total PDSS score was lower in PD patients than controls: 114.9 ± 28.8 vs 132.8 ± 16.3 (p < 0.0001). Quality of life (QoL) was worse in PD patients with sleep problems compared to those without: PDQ-39SI, 19.3 ± 14 vs 13 ± 11.6 (p < 0.0001); EUROHIS-QoL8, 3.7 ± 0.5 vs 3.9 ± 0.5 (p < 0.0001). Non-motor symptoms burden (NMSS; OR = 1.029; 95%CI 1.015–1.043; p < 0.0001) and impulse control behaviors (QUIP-RS; OR = 1.054; 95%CI 1.009–1.101; p = 0.018) were associated with sleep problems after adjustment for age, gender, disease duration, daily equivalent levodopa dose, H&Y, UPDRS-III, UPDRS-IV, PD-CRS, BDI-II, NPI, VAS-Pain, VAFS, FOGQ, and total number of non-antiparkinsonian treatments.
Conclusion:
Sleep problems were frequent in PD patients and were related to both a worse QoL and a greater non-motor symptoms burden in PD. These findings call for increased awareness of sleep problems in PD patients.
eng
info:eu-repo/semantics/openAccess
Non-motor symptoms
Parkinson’s disease
Parkinson’s disease sleep scale
Quality of life
Sleep
Sleep Problems Are Related to a Worse Quality of Life and a Greater Non-Motor Symptoms Burden in Parkinson’s Disease
info:eu-repo/semantics/article