2026-08-19T10:11:18Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/88092024-03-13T01:05:29Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220
Martínez-Horta, Saul
Berj-Kasem, Helena
Horta-Barba, Andrea
Pascual Sedano, Berta
Santos García, Diego
Deus-Fonticoba, Teresa de
Jesús, Silvia
Aguilar, Miquel
Planellás, Lluis L.
García Caldentey, Juan
Caballol, Núria
Vives Pastor, Bárbara
Hernández Vara, Jorge
Cabo López, Iria
López Manzanares, Lydia
González Aramburu, Isabel
Ávila Rivera, María A.
Catalán, María José
López Díaz, Luis M.
Puente, Víctor
García Moreno, José Manuel
Borrue, Carmen
Solano Vila, Berta
Álvarez Saúco, María
Vela Desojo, Lydia
Escalante Arroyo, Sonia
Cubo Delgado, Esther
Carrillo Padilla, Francisco
Martínez Castrillo, Juan Carlos
Sánchez Alonso, Pilar
Alonso Losada, María Gema
López Ariztegui, Nuria
Gastón, Itziar
Blázquez Estrada, Marta
Seijo, Manuel
Ruíz Martínez, Javier
Valero, Caridad
Kurtis, Mónica M.
Fabregues, Oriol de
González Ardura, Jessica
Prieto Jurczynska, Cristina
Martínez Martín, Pablo
Mir, Pablo
Kulisevsky Bojarsky, Jaume
COPPADIS Study Group
2024-03-12T12:19:24Z
2024-03-12T12:19:24Z
2021-12
http://hdl.handle.net/10259/8809
10.1186/s12883-021-02485-1
1471-2377
Background: Identifying modifable risk factors for cognitive impairment in the early stages of Parkinson’s disease
(PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive
trials.
Methods: Using a standard approach for the assessment of global cognition in PD and controlling for the efects of
age, education and disease duration, we explored the associations between cognitive status, comorbidities, meta‑
bolic variables and lifestyle variables in 533 PD participants from the COPPADIS study.
Results: Among the overall sample, 21% of participants were classifed as PD-MCI (n=114) and 4% as PDD (n=26).
The prevalence of hypertension, diabetes and dyslipidemia was signifcantly higher in cognitively impaired patients
while no between-group diferences were found for smoking, alcohol intake or use of supplementary vitamins. Bet‑
ter cognitive scores were signifcantly associated with regular physical exercise (p<0.05) and cognitive stimulation
(<0.01). Cognitive performance was negatively associated with interleukin 2 (Il2) (p<0.05), Il6 (p<0.05), iron (p<0.05),
and homocysteine (p<0.005) levels, and positively associated with vitamin B12 levels (p<0.005).
Conclusions: We extend previous fndings regarding the positive and negative infuence of various comorbidities
and lifestyle factors on cognitive status in early PD patients, and reinforce the need to identify and treat potentially
application/pdf
eng
Springer Nature
BMC Neurology. 2021, V. 21, n. 1
https://doi.org/10.1186/s12883-021-02485-1
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
Parkinson’s disease
PD-MCI
Cognition
Lifestyle
Coppadis
Sistema nervioso-Enfermedades
Medicina
Neurología
Nervous system-Diseases
Medicine
Neurology
Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
BMC Neurology
21
1