2026-06-19T13:03:25Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/88092024-03-13T01:05:29Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220

00925njm 22002777a 4500 dc Martínez-Horta, Saul author Berj-Kasem, Helena author Horta-Barba, Andrea author Pascual Sedano, Berta author Santos García, Diego author Deus-Fonticoba, Teresa de author Jesús, Silvia author Aguilar, Miquel author Planellás, Lluis L. author García Caldentey, Juan author Caballol, Núria author Vives Pastor, Bárbara author Hernández Vara, Jorge author Cabo López, Iria author López Manzanares, Lydia author González Aramburu, Isabel author Ávila Rivera, María A. author Catalán, María José author López Díaz, Luis M. author Puente, Víctor author García Moreno, José Manuel author Borrue, Carmen author Solano Vila, Berta author Álvarez Saúco, María author Vela Desojo, Lydia author Escalante Arroyo, Sonia author Cubo Delgado, Esther author Carrillo Padilla, Francisco author Martínez Castrillo, Juan Carlos author Sánchez Alonso, Pilar author Alonso Losada, María Gema author López Ariztegui, Nuria author Gastón, Itziar author Blázquez Estrada, Marta author Seijo, Manuel author Ruíz Martínez, Javier author Valero, Caridad author Kurtis, Mónica M. author Fabregues, Oriol de author González Ardura, Jessica author Prieto Jurczynska, Cristina author Martínez Martín, Pablo author Mir, Pablo author Kulisevsky Bojarsky, Jaume author COPPADIS Study Group author 2021-12 Background: Identifying modifable risk factors for cognitive impairment in the early stages of Parkinson’s disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials. Methods: Using a standard approach for the assessment of global cognition in PD and controlling for the efects of age, education and disease duration, we explored the associations between cognitive status, comorbidities, meta‑ bolic variables and lifestyle variables in 533 PD participants from the COPPADIS study. Results: Among the overall sample, 21% of participants were classifed as PD-MCI (n=114) and 4% as PDD (n=26). The prevalence of hypertension, diabetes and dyslipidemia was signifcantly higher in cognitively impaired patients while no between-group diferences were found for smoking, alcohol intake or use of supplementary vitamins. Bet‑ ter cognitive scores were signifcantly associated with regular physical exercise (p<0.05) and cognitive stimulation (<0.01). Cognitive performance was negatively associated with interleukin 2 (Il2) (p<0.05), Il6 (p<0.05), iron (p<0.05), and homocysteine (p<0.005) levels, and positively associated with vitamin B12 levels (p<0.005). Conclusions: We extend previous fndings regarding the positive and negative infuence of various comorbidities and lifestyle factors on cognitive status in early PD patients, and reinforce the need to identify and treat potentially http://hdl.handle.net/10259/8809 10.1186/s12883-021-02485-1 1471-2377 Parkinson’s disease PD-MCI Cognition Lifestyle Coppadis Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease