2026-06-17T21:39:54Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/88092024-03-13T01:05:29Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220
Repositorio Institucional de la Universidad de Burgos
author
Martínez-Horta, Saul
author
Berj-Kasem, Helena
author
Horta-Barba, Andrea
author
Pascual Sedano, Berta
author
Santos García, Diego
author
Deus-Fonticoba, Teresa de
author
Jesús, Silvia
author
Aguilar, Miquel
author
Planellás, Lluis L.
author
García Caldentey, Juan
author
Caballol, Núria
author
Vives Pastor, Bárbara
author
Hernández Vara, Jorge
author
Cabo López, Iria
author
López Manzanares, Lydia
author
González Aramburu, Isabel
author
Ávila Rivera, María A.
author
Catalán, María José
author
López Díaz, Luis M.
author
Puente, Víctor
author
García Moreno, José Manuel
author
Borrue, Carmen
author
Solano Vila, Berta
author
Álvarez Saúco, María
author
Vela Desojo, Lydia
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Escalante Arroyo, Sonia
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Cubo Delgado, Esther
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Carrillo Padilla, Francisco
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Martínez Castrillo, Juan Carlos
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Sánchez Alonso, Pilar
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Alonso Losada, María Gema
author
López Ariztegui, Nuria
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Gastón, Itziar
author
Blázquez Estrada, Marta
author
Seijo, Manuel
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Ruíz Martínez, Javier
author
Valero, Caridad
author
Kurtis, Mónica M.
author
Fabregues, Oriol de
author
González Ardura, Jessica
author
Prieto Jurczynska, Cristina
author
Martínez Martín, Pablo
author
Mir, Pablo
author
Kulisevsky Bojarsky, Jaume
author
COPPADIS Study Group
2024-03-12T12:19:24Z
2024-03-12T12:19:24Z
2021-12
http://hdl.handle.net/10259/8809
10.1186/s12883-021-02485-1
1471-2377
Background: Identifying modifable risk factors for cognitive impairment in the early stages of Parkinson’s disease
(PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive
trials.
Methods: Using a standard approach for the assessment of global cognition in PD and controlling for the efects of
age, education and disease duration, we explored the associations between cognitive status, comorbidities, meta‑
bolic variables and lifestyle variables in 533 PD participants from the COPPADIS study.
Results: Among the overall sample, 21% of participants were classifed as PD-MCI (n=114) and 4% as PDD (n=26).
The prevalence of hypertension, diabetes and dyslipidemia was signifcantly higher in cognitively impaired patients
while no between-group diferences were found for smoking, alcohol intake or use of supplementary vitamins. Bet‑
ter cognitive scores were signifcantly associated with regular physical exercise (p<0.05) and cognitive stimulation
(<0.01). Cognitive performance was negatively associated with interleukin 2 (Il2) (p<0.05), Il6 (p<0.05), iron (p<0.05),
and homocysteine (p<0.005) levels, and positively associated with vitamin B12 levels (p<0.005).
Conclusions: We extend previous fndings regarding the positive and negative infuence of various comorbidities
and lifestyle factors on cognitive status in early PD patients, and reinforce the need to identify and treat potentially
eng
Atribución 4.0 Internacional
Parkinson’s disease
PD-MCI
Cognition
Lifestyle
Coppadis
Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease
info:eu-repo/semantics/article
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URL
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