2026-08-19T08:34:48Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/88252024-03-15T01:05:25Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220

Santos García, Diego Deus-Fonticoba, Teresa de Cores Bartolomé, Carlos Feal Painceiras, María García Díaz, Iago Íñiguez Alvarado, María Cristina Paz González, José Manuel Jesús, Silvia Cosgaya, Marina García Caldentey, Juan Caballol, Núria Legarda, Inés Hernández Vara, Jorge Cabo López, Iria López Manzanares, Lydia González Aramburu, Isabel Ávila Rivera, María A. Gómez Mayordomo, Víctor Nogueira, Víctor Dotor, Julio Borrue, Carmen Solano Vila, Berta Álvarez Saúco, María Vela Desojo, Lydia Escalante Arroyo, Sonia Cubo Delgado, Esther Mendoza, Zebenzui Martínez Castrillo, Juan Carlos Sánchez Alonso, Pilar Alonso Losada, María Gema López Ariztegui, Nuria Gastón, Itziar Kulisevsky Bojarsky, Jaume Seijo, Manuel Valero, Caridad Alonso Redondo, Rubén Buongiorno, María Teresa Ordás Bandera, Carlos Manuel Menéndez González, Manuel McAfee, Darrian Martínez Martín, Pablo Mir, Pablo COPPADIS Study Group 2024-03-14T12:56:10Z 2024-03-14T12:56:10Z 2023-11 2162-3279 http://hdl.handle.net/10259/8825 10.1002/brb3.3295 2162-3279 Background and objective: Recently, we demonstrated that staging Parkinson's disease (PD) with a novel simple classification called MNCD, based on four axes (motor, non-motor, cognition, and dependency) and five stages, correlated with disease severity and patients’ quality of life. Here, we analyzed the correlation of MNCD staging with PD caregiver's status. Patients and methods: Data from the baseline visit of PD patients and their principal caregiver recruited from 35 centers in Spain from the COPPADIS cohort from January 2016 to November 2017 were used to apply the MNCD total score (from 0 to 12) and MNCD stages (from 1 to 5) in this cross-sectional analysis. Caregivers completed the Zarit Caregiver Burden Inventory (ZCBI), Caregiver Strain Index (CSI), Beck Depression Inventory-II (BDI-II), PQ-10, and EUROHIS-QOL 8-item index (EUROHIS-QOL8). Results: Two hundred and twenty-four PD patients (63 ± 9.6 years old; 61.2% males) and their caregivers (58.5 ± 12.1 years old; 67.9% females) were included. The frequency of MNCD stages was 1, 7.6%; 2, 58.9%; 3, 31.3%; and 4–5, 2.2%. A more advanced MNCD stage was associated with a higher score on the ZCBI (p < .0001) and CSI (p < .0001), and a lower score on the PQ-10 (p = .001), but no significant differences were observed in the BDI-II (p = .310) and EUROHIS-QOL8 (p = .133). Moderate correlations were observed between the MNCD total score and the ZCBI (r = .496; p < .0001), CSI (r = .433; p < .0001), and BDI-II (r = .306; p < .0001) in caregivers. Conclusion: Staging PD according to the MNCD classification is correlated with caregivers’ strain and burden. application/pdf eng Wiley Brain and Behavior. 2023, V. 13, n. 12 https://doi.org/10.1002/brb3.3295 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Burden Caregiver Non-motor symptoms Parkinson’s disease Stage Sistema nervioso-Enfermedades Medicina Neurología Nervous system-Diseases Medicine Neurology Staging Parkinson's disease according to the MNCD classification correlates with caregiver burden info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Brain and Behavior 13 12