2026-06-17T20:24:08Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/88262024-03-15T01:05:28Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220

Santos García, Diego Deus-Fonticoba, Teresa de Cores Bartolomé, Carlos Feal Painceiras, María Íñiguez Alvarado, María Cristina García Díaz, Iago Jesús, Silvia Buongiorno, María Teresa Planellás, Lluis L. Cosgaya, Marina García Caldentey, Juan Caballol, Núria Legarda, Inés Hernández Vara, Jorge Cabo López, Iria López Manzanares, Lydia González Aramburu, Isabel Ávila Rivera, María A. Gómez Mayordomo, Víctor Nogueira, Víctor Puente, Víctor Dotor, Julio Borrue, Carmen Solano Vila, Berta Álvarez Saúco, María Vela Desojo, Lydia Escalante Arroyo, Sonia Cubo Delgado, Esther Carrillo Padilla, Francisco Martínez Castrillo, Juan Carlos Sánchez Alonso, Pilar Alonso Losada, María Gema López Ariztegui, Nuria Gastón, Itziar Kulisevsky Bojarsky, Jaume Menéndez González, Manuel Seijo, Manuel Ruíz Martínez, Javier Valero, Caridad Kurtis, Mónica M. González Ardura, Jessica Alonso Redondo, Rubén Ordás Bandera, Carlos Manuel López Díaz, Luis M. McAfee, Darrian Calopa, Matilde Carrillo, Fátima Escamilla-Sevilla, Francisco Freire-Alvarez, Eric Gómez Esteban, Juan Carlos García Ramos, Rocío Luquin Piudo, Mª Rosario Martínez Torres, Irene Sesar Ignacio, Ángel Martínez Martín, Pablo Mir, Pablo 2024-03-14T13:14:13Z 2024-03-14T13:14:13Z 2023-05 1877-7171 http://hdl.handle.net/10259/8826 10.3233/JPD-225073 1877-718X Background: Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has been proposed to classify Parkinson's disease (PD). Objective: Our aim was to apply the MNCD classification in a cohort of PD patients for the first time and also to analyze the correlation with quality of life (QoL) and disease severity. Methods: Data from the baseline visit of PD patients recruited from 35 centers in Spain from the COPPADIS cohort fromJanuary 2016 to November 2017 were used to apply the MNCD classification. Three instruments were used to assess QoL:1) the 39-item Parkinson's disease Questionnaire [PDQ-39]); PQ-10; the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Results: Four hundred and thirty-nine PD patients (62.05±7.84 years old; 59% males) were included. MNCD stage was:stage 1, 8.4% (N = 37); stage 2, 62% (N = 272); stage 3, 28.2% (N = 124); stage 4-5, 1.4% (N = 6). A more advancedMNCD stage was associated with a higher score on the PDQ39SI (p < 0.0001) and a lower score on the PQ-10 (p< 0.0001) and EUROHIS-QOL8 (p< 0.0001). In many other aspects of the disease, such as disease duration, levodopa equivalent daily dose, motor symptoms, non-motor symptoms, and autonomy for activities of daily living, an association between the stage and severity was observed, with data indicating a progressive worsening related to disease progression throughout the proposed stages. Conclusion: Staging PD according to the MNCD classification correlated with QoL and disease severity. The MNCD could be a proper tool to monitor the progression of PD. The supplementary material is available in the electronic version of this article: https://dx.doi.org/ 10.3233/JPD-225073. application/pdf eng IOS Press Journal of Parkinson's Disease. 2023, V. 13, n. 3, p. 379-402 https://content.iospress.com/articles/journal-of-parkinsons-disease/jpd225073 Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess Axial symptoms Cognition MNCD classification Non-motor symptoms Parkinson’s disease Quality of life Sistema nervioso-Enfermedades Medicina Neurología Nervous system-Diseases Medicine Neurology Staging Parkinson’s Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Journal of Parkinson's Disease 13 3 379 402