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oai:riubu.ubu.es:10259/88262024-03-15T01:05:28Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220

00925njm 22002777a 4500 dc Santos García, Diego author Deus-Fonticoba, Teresa de author Cores Bartolomé, Carlos author Feal Painceiras, María author Íñiguez Alvarado, María Cristina author García Díaz, Iago author Jesús, Silvia author Buongiorno, María Teresa author Planellás, Lluis L. author Cosgaya, Marina author García Caldentey, Juan author Caballol, Núria author Legarda, Inés author Hernández Vara, Jorge author Cabo López, Iria author López Manzanares, Lydia author González Aramburu, Isabel author Ávila Rivera, María A. author Gómez Mayordomo, Víctor author Nogueira, Víctor author Puente, Víctor author Dotor, Julio author Borrue, Carmen author Solano Vila, Berta author Álvarez Saúco, María author Vela Desojo, Lydia author Escalante Arroyo, Sonia author Cubo Delgado, Esther author Carrillo Padilla, Francisco author Martínez Castrillo, Juan Carlos author Sánchez Alonso, Pilar author Alonso Losada, María Gema author López Ariztegui, Nuria author Gastón, Itziar author Kulisevsky Bojarsky, Jaume author Menéndez González, Manuel author Seijo, Manuel author Ruíz Martínez, Javier author Valero, Caridad author Kurtis, Mónica M. author González Ardura, Jessica author Alonso Redondo, Rubén author Ordás Bandera, Carlos Manuel author López Díaz, Luis M. author McAfee, Darrian author Calopa, Matilde author Carrillo, Fátima author Escamilla-Sevilla, Francisco author Freire-Alvarez, Eric author Gómez Esteban, Juan Carlos author García Ramos, Rocío author Luquin Piudo, Mª Rosario author Martínez Torres, Irene author Sesar Ignacio, Ángel author Martínez Martín, Pablo author Mir, Pablo author 2023-05 Background: Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has been proposed to classify Parkinson's disease (PD). Objective: Our aim was to apply the MNCD classification in a cohort of PD patients for the first time and also to analyze the correlation with quality of life (QoL) and disease severity. Methods: Data from the baseline visit of PD patients recruited from 35 centers in Spain from the COPPADIS cohort fromJanuary 2016 to November 2017 were used to apply the MNCD classification. Three instruments were used to assess QoL:1) the 39-item Parkinson's disease Questionnaire [PDQ-39]); PQ-10; the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Results: Four hundred and thirty-nine PD patients (62.05±7.84 years old; 59% males) were included. MNCD stage was:stage 1, 8.4% (N = 37); stage 2, 62% (N = 272); stage 3, 28.2% (N = 124); stage 4-5, 1.4% (N = 6). A more advancedMNCD stage was associated with a higher score on the PDQ39SI (p < 0.0001) and a lower score on the PQ-10 (p< 0.0001) and EUROHIS-QOL8 (p< 0.0001). In many other aspects of the disease, such as disease duration, levodopa equivalent daily dose, motor symptoms, non-motor symptoms, and autonomy for activities of daily living, an association between the stage and severity was observed, with data indicating a progressive worsening related to disease progression throughout the proposed stages. Conclusion: Staging PD according to the MNCD classification correlated with QoL and disease severity. The MNCD could be a proper tool to monitor the progression of PD. 1877-7171 http://hdl.handle.net/10259/8826 10.3233/JPD-225073 1877-718X Axial symptoms Cognition MNCD classification Non-motor symptoms Parkinson’s disease Quality of life Staging Parkinson’s Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life