2026-05-11T14:44:02Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/88292024-03-16T01:05:05Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220
Santos García, Diego
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Jesús, Silvia
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Nogueira, Víctor
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Puente, Víctor
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Dotor, Julio
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Borrue, Carmen
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Solano Vila, Berta
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Álvarez Saúco, María
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Sánchez Alonso, Pilar
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Alonso Losada, María Gema
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López Ariztegui, Nuria
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Gastón, Itziar
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Kulisevsky Bojarsky, Jaume
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Blázquez Estrada, Marta
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Seijo, Manuel
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Kurtis, Mónica M.
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Fabregues, Oriol de
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González Ardura, Jessica
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Alonso Redondo, Rubén
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Ordás Bandera, Carlos Manuel
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López Díaz, Luis M.
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McAfee, Darrian
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Martínez Martín, Pablo
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Mir, Pablo
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COPPADIS Study Group
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2024-03-15T08:22:10Z
2024-03-15T08:22:10Z
2023-01
1738-6586
http://hdl.handle.net/10259/8829
10.3988/jcn.2022.0186
2005-5013
Background and Purpose: Visual hallucinations (VH) and subjective cognitive complaints (SCC) are associated with cognitive impairment (CI) in Parkinson’s disease. Our aims were to determine the association between VH and SCC and the risk of CI development in a cohort of patients with Parkinson’s disease and normal cognition (PD-NC).
Methods: Patients with PD-NC (total score of >80 on the Parkinson’s Disease Cognitive Rating Scale [PD-CRS]) recruited from the Spanish COPPADIS cohort from January 2016 to November 2017 were followed up after 2 years. Subjects with a score of ≥1 on domain 5 and item 13 of the Non-Motor Symptoms Scale at baseline (V0) were considered as “with SCC” and “with VH,” respectively. CI at the 2-year follow-up (plus or minus 1 month) (V2) was defined as a PD-CRS total score of <81.
Results: At V0 (n=376, 58.2% males, age 61.14±8.73 years [mean±SD]), the frequencies of VH and SCC were 13.6% and 62.2%, respectively. VH were more frequent in patients with SCC than in those without: 18.8% (44/234) vs 4.9% (7/142), p<0.0001. At V2, 15.2% (57/376) of the patients had developed CI. VH presenting at V0 was associated with a higher risk of CI at V2 (odds ratio [OR]=2.68, 95% confidence interval=1.05–6.83, p=0.0.039) after controlling for the effects of age, disease duration, education, medication, motor and nonmotor status, mood, and PD-CRS total score at V0. Although SCC were not associated with CI at V2, presenting both VH and SCC at V0 increased the probability of having CI at V2 (OR=3.71, 95% confidence interval=1.36–10.17, p=0.011).
Conclusions: VH were associated with the development of SCC and CI at the 2-year follow-up in patients with PD-NC.
The resources obtained for the development of this project have been obtained by the Degen Foundation (https://fundaciondegen.org/). A part of the Project is financed with grants from the Spanish Ministry of Economy and Competitiveness [PI16/01575] co-founded by ISCIII (Concesión de subvenciones de Proyectos de Investigación en Salud de la convocatoria 2020 de la Acción Estratégica en Salud 2017-2020 por el proyecto “PROGRESIÓN NO MOTORA E IMPACTO EN LA CALIDAD DE VIDA EN LA ENFERMEDAD DE PARKINSON”).
application/pdf
eng
Korean Neurological Association
Journal of Clinical Neurology. 2023, V. 19, n. 4, p. 344-357
https://doi.org/10.3988/jcn.2022.0186
Atribución-NoComercial 4.0 Internacional
http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
Cognitive impairment
Dementia
Parkinson’s disease
Subjective cognitive complaints
Visual hallucinations
Sistema nervioso-Enfermedades
Medicina
Neurología
Nervous system-Diseases
Medicine
Neurology
Risk of Cognitive Impairment in Patients With Parkinson’s Disease With Visual Hallucinations and Subjective Cognitive Complaints
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Journal of Clinical Neurology
19
4
344
357
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Santos-jcn_2023.pdf
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10259/8829
oai:riubu.ubu.es:10259/8829
2024-03-16 02:05:05.872
Repositorio Institucional de la Universidad de Burgos
bubrep@ubu.es
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