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<mods:namePart>COPPADIS Study Group</mods:namePart>
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<mods:dateAccessioned encoding="iso8601">2024-03-20T11:06:10Z</mods:dateAccessioned>
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<mods:dateIssued encoding="iso8601">2023-03</mods:dateIssued>
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<mods:identifier type="issn">1877-7171</mods:identifier>
<mods:identifier type="uri">http://hdl.handle.net/10259/8856</mods:identifier>
<mods:identifier type="doi">10.3233/JPD-225014</mods:identifier>
<mods:identifier type="essn">1877-718X</mods:identifier>
<mods:abstract>Background: Although many studies have analyzed what factors contribute to caregiver burden in Parkinson’s disease (PD),&#xd;
there is currently no knowledge about how the status of the caregiver could impact the patient.&#xd;
Objective: The aim of this study was to analyze how the change in the caregiver’s status influences PD patients.&#xd;
Methods: PD patients and their caregivers who were recruited from January/2016 to November/2017 from 35 centers&#xd;
in Spain from the COPPADIS cohort were included in the study (V0). They were evaluated again at 2-year follow-up&#xd;
(V2). Caregivers completed the Zarit Caregiver Burden Inventory (ZCBI), Caregiver Strain Index (CSI), Beck Depression Inventory-II (BDI-II), and EUROHIS-QOL 8-item index (EUROHIS-QOL8) at V0 and V2. Multivariate models were&#xd;
used to analyze the impact of the change from V0 to V2 () on the caregiver’s status over the change in the patient’s&#xd;
status.&#xd;
Results: BDI-II and EUROHIS-QOL8 in the caregiver predicted BDI-II ( = 0.32; p &lt; 0.0001; R2 = 0.71) and&#xd;
EUROHIS-QOL8 ( = 0.39; p &lt; 0.0001; R2 = 0.68) in the patient, respectively. Variables related to the caregiver were&#xd;
not associated with changes in the patient´s health-related QoL (PDQ-39 [39-item Parkinson’s disease Questionnaire]) or&#xd;
autonomy for activities of daily-living (ADLS [Schwab &amp; England Activities of Daily Living Scale]).&#xd;
Conclusion: The change in the caregiver’s mood and global QoL was associated with the change in the patient’s mood and&#xd;
global QoL, respectively, independently of other variables of the disease influencing both patient´s aspects. Based on this&#xd;
finding, it could be of great importance to detect depression in the principal caregiver of a patient and act on it as earlier as&#xd;
possible.</mods:abstract>
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<mods:languageTerm authority="rfc3066">eng</mods:languageTerm>
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<mods:accessCondition type="useAndReproduction">Atribución-NoComercial 4.0 Internacional</mods:accessCondition>
<mods:subject>
<mods:topic>Caregiver</mods:topic>
</mods:subject>
<mods:subject>
<mods:topic>Longitudinal</mods:topic>
</mods:subject>
<mods:subject>
<mods:topic>Mood</mods:topic>
</mods:subject>
<mods:subject>
<mods:topic>Parkinson’s disease</mods:topic>
</mods:subject>
<mods:subject>
<mods:topic>Quality of life</mods:topic>
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<mods:titleInfo>
<mods:title>Changes in Principal Caregiver Mood Affects the Mood of the Parkinson’s Disease Patient: The Vicious Cycle of Illness</mods:title>
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