2026-06-17T21:32:16Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/88582024-03-21T01:05:20Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220

Kim, Jonggeol Jeffrey Vitale, Dan Véliz Otani, Diego Lian, Michelle Mulan Heilbron, Karl 23andMe Research Team Iwaki, Hirotaka Lake, Julie Warly Solsberg, Caroline Leonard, Hampton Makarious, Mary B. Tan, Eng-King Singleton, Andrew B. Bandres-Ciga, Sara Noyce, Alastair J. Cubo Delgado, Esther Global Parkinson's Genetics Program Blauwendraat, Cornelis Nalls, Mike A. Nee Foo, Jia Mata, Ignacio 2024-03-20T11:57:55Z 2024-03-20T11:57:55Z 2023-12 1546-1718 http://hdl.handle.net/10259/8858 10.1038/s41588-023-01584-8 1061-4036 Although over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson’s disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with publicly available eQTL data, we identified 25 putative risk genes in these novel loci whose expression is associated with PD risk. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations. application/pdf eng Springer Nature Nature Genetics. 2024, V. 56, n. 1, p. 27-36 https://doi.org/10.1038/s41588-023-01584-8 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Sistema nervioso-Enfermedades Medicina Neurología Nervous system-Diseases Medicine Neurology Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Nature Genetics 56 1 27 36