2026-09-16T06:59:08Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/88582024-03-21T01:05:20Zcom_10259_4219com_10259_5086com_10259_2604col_10259_4220

00925njm 22002777a 4500 dc Kim, Jonggeol Jeffrey author Vitale, Dan author Véliz Otani, Diego author Lian, Michelle Mulan author Heilbron, Karl author 23andMe Research Team author Iwaki, Hirotaka author Lake, Julie author Warly Solsberg, Caroline author Leonard, Hampton author Makarious, Mary B. author Tan, Eng-King author Singleton, Andrew B. author Bandres-Ciga, Sara author Noyce, Alastair J. author Cubo Delgado, Esther author Global Parkinson's Genetics Program author Blauwendraat, Cornelis author Nalls, Mike A. author Nee Foo, Jia author Mata, Ignacio author 2023-12 Although over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson’s disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with publicly available eQTL data, we identified 25 putative risk genes in these novel loci whose expression is associated with PD risk. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations. 1546-1718 http://hdl.handle.net/10259/8858 10.1038/s41588-023-01584-8 1061-4036 Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease