2026-05-07T08:02:40Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/93162024-07-02T00:05:21Zcom_10259_4363com_10259_5086com_10259_2604col_10259_4364

Taghizadeh Shool, Maryam ed80bcfc-ef5b-4ce7-94f1-5de1a317c1cf 600 Amiri Rudbari, Hadi b2990e32-ba5f-4dc8-bfa7-bcb525b5496f 600 Cuevas Vicario, José Vicente 137 600 0000-0002-2421-1529 Rodríguez Rubio, Andrea 3b64d0b4-5f21-4556-a88e-94259de069e2 600 Stagno, Claudio 11edaefd-0d1a-4495-a423-6e35ddda9447 600 Iraci, Nunzio c30f1343-80f3-4a22-99eb-c00a84508afa 600 Efferth, Thomas 06eb49bf-c9ff-44ab-90ca-34a6925532a2 600 Omer, Ejlal A. 2e07b1ac-7ecf-4223-9a00-41fd892bf1e3 600 Schirmeister, Tanja e3fc1f65-43c0-48f0-8e4c-156796dc1af7 600 Blacque, Olivier d12dd3ec-2f8e-412a-ad75-62191c77b3cd 600 Moini, Nakisa 7cf56367-ddfd-461f-8d58-a9fde34e49b0 600 Sheibani, Esmail 6f123a4d-fb74-46c3-b38f-4aa5f28bd6b5 600 2024-07-01T06:53:20Z 2024-07-01T06:53:20Z 2023-12-29 0020-1669 http://hdl.handle.net/10259/9316 10.1021/acs.inorgchem.3c03414 1520-510X A novel class of Ru(II)-based polypyridyl complexes with an auxiliary salicylaldehyde ligand [Ru(phen)2(X-Sal)]BF4 {X: H (1), 5-Cl (2), 5-Br (3), 3,5-Cl2 (4), 3,5-Br2 (5), 3-Br,5-Cl (6), 3,5-I2 (7), 5-NO2 (8), 5-Me (9), 4-Me (10), 4-OMe (11), and 4-DEA (12), has been synthesized and characterized by elemental analysis, FT-IR, and 1H/13C NMR spectroscopy. The molecular structure of 4, 6, 9, 10, and 11 was determined by single-crystal X-ray diffraction analysis which revealed structural similarities. DFT and TD-DFT calculations showed that they also possess similar electronic structures. Absorption/emission spectra were recorded for 2, 3, 10, and 11. All Ru-complexes, unlike the pure ligands and the complex lacking the salicylaldehyde component, displayed outstanding antiproliferative activity in the screening test (10 μM) against CCRF-CEM leukemia cells underlining the crucial role of the presence of the auxiliary ligand for the biological activity. The two most active derivatives, namely 7 and 10, were selected for continuous assays showing IC50 values in the submicromolar and micromolar range against drug-sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 leukemia cells, respectively. These two compounds were investigated in silico for their potential binding to duplex DNA well-matched and mismatched base pairs, since they showed remarkable selectivity indexes (2.2 and 19.5 respectively) on PBMC cells. This work is based upon research funded by Iran national science foundation (INSF) under project no.4005765. application/pdf eng ACS Publications Inorganic Chemistry. 2023, V. 63, n. 2, p. 1083-1101 https://doi.org/10.1021/acs.inorgchem.3c03414 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Química inorgánica Cáncer Chemistry, Inorganic Cancer Investigating the Cytotoxicity of Ru(II) Polypyridyl Complexes by Changing the Electronic Structure of Salicylaldehyde Ligands info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Inorganic Chemistry 63 2 1083 1101 THUMBNAIL Taghizadeh-ic_2023.pdf.jpg Taghizadeh-ic_2023.pdf.jpg IM Thumbnail image/jpeg 5466 https://riubu.ubu.es/bitstream/10259/9316/4/Taghizadeh-ic_2023.pdf.jpg 04bbe7ae199e30fe8faeeaca5d8e5ed6 MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 998 https://riubu.ubu.es/bitstream/10259/9316/3/license.txt aa90105e1c90a1b4fe810649aa967b7d MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 908 https://riubu.ubu.es/bitstream/10259/9316/2/license_rdf 0175ea4a2d4caec4bbcc37e300941108 MD5 2 ORIGINAL Taghizadeh-ic_2023.pdf Taghizadeh-ic_2023.pdf application/pdf 8029590 https://riubu.ubu.es/bitstream/10259/9316/1/Taghizadeh-ic_2023.pdf 1c61d9a4cf60bc3eedd9e1066cded5ca MD5 1 10259/9316 oai:riubu.ubu.es:10259/9316 2024-07-02 02:05:21.841 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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