2026-05-07T06:16:52Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/93252024-07-02T00:05:30Zcom_10259_3596com_10259_5086com_10259_2604com_10259_3593col_10259_3597col_10259_3594

Hernández Ruiz, Raquel Gómez Gil, Sara Pedrosa Sáez, María de los Remedios Suarez Pantiga, Samuel Sanz Díez, Roberto 2024-07-01T06:55:37Z 2024-07-01T06:55:37Z 2023-09-08 1477-0520 http://hdl.handle.net/10259/9325 10.1039/D3OB01187A 1477-0539 Herein, we report the direct synthesis of a wide variety of functionalized aromatic bromides, chlorides, iodides, and fluorides from nitroarenes in a sequential one-pot operation. This protocol is based on an air- and moisture-tolerant dioxomolybdenum-catalyzed reduction of nitroaromatics, employing pinacol as a reducing agent, which enables subsequent diazotization and halogenation steps. This methodology represents a step-economical, practical, and alternative procedure for synthesizing haloaromatics directly from nitroaromatics. We gratefully acknowledge the Ministerio de Ciencia e Innovación MCIN/AEI/10.13039/501100011033 (PID2020-115789GB-C21) and the Junta de Castilla y León and FEDER (BU049P20) for financial support. R. H.-R. and S. G.-G. thank the Ministerio de Educación for FPU predoctoral contracts. S. S.-P. thanks the Ministerio de Ciencia e Innovación and the “NextGenerationEU”/PRTR EU for a Ramón y Cajal contract (RYC2021-031533-I). application/pdf eng Royal Society of Chemistry Organic & Biomolecular Chemistry. 2023, V. 21, n. 38, p. 7791-7798 https://doi.org/10.1039/D3OB01187A Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess Química orgánica Biología molecular Chemistry, Organic Molecular biology Direct synthesis of haloaromatics from nitroarenes via a sequential one-pot Mo-catalyzed reduction/Sandmeyer reaction info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Organic & Biomolecular Chemistry 21 38 7791 7798